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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The i allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease
Coronary Artery Disease, Volume 21, No. 3, Year 2010
Notification
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Description
Background: Mutations in genes regulating lipid metabolism, vasoactivity, and coagulation are important modulators of coronary artery disease (CAD). Objective: This study investigated the association between allelic variants of the angiotensin converting enzyme (ACE), methytetrahydrofolate reductase, plasminogen activator inhibitor-1 and factor V genes and CAD. Methods: Clinical, biochemical, and angiographic information were collected from 300 patients who underwent cardiac catheterization and their DNA was genotyped by restriction fragment length polymorphism. Results: The frequency of the D allele of the ACE gene was significantly higher than the I allele in patients with more than 70% stenosis in any vessel. Among patients with more than 70% stenosis, carriers of the D allele were 2.8 times more likely to be males. The presence of the ACE I allele was negatively associated with CAD with (P=0.02 ,OR=0.38.) Conclusion: This study describes a protective role of the ACE I allele in individuals who may be at risk of developing CAD. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
AbchÉE, Antoine B.
Lebanon, Beirut
American University of Beirut
El-Sibai, Mirvat
Lebanon, Beirut
Lebanese American University
Youhanna, Sonia C.
Lebanon, Beirut
Lebanese American University
Yérétzian, Joumana Stephan
Lebanon, Beirut
Lebanese American University
Estephan, Hanine C.
Lebanon, Beirut
Lebanese American University
Makhoul, Nadine J.
Lebanon, Beirut
Lebanese American University
Puzantian, Houry V.
Lebanon, Beirut
American University of Beirut
Sawaya, Jaber I.
Lebanon, Beirut
American University of Beirut
Nasrallah, Antoine T.
Lebanon, Beirut
American University of Beirut
Rebeiz, Abdallah G.
Lebanon, Beirut
American University of Beirut
Zreik, Tony G.
Lebanon, Beirut
American University of Beirut
Azar, Sami T.
Lebanon, Beirut
American University of Beirut
Zalloua, Pierre A.
Lebanon, Beirut
Lebanese American University
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 13
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1097/MCA.0b013e328335a042
ISSN:
09546928
Research Areas
Genetics And Genomics
Noncommunicable Diseases