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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Population-specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO-PD) consortium
Movement Disorders, Volume 28, No. 12, Year 2013
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Description
Background: Variants within the leucine-rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine-rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late-onset sporadic disorders like Parkinson's disease. Methods: The Genetic Epidemiology of Parkinson's Disease Consortium recently performed the largest genetic association study for variants in the leucine-rich repeat kinase 2 gene across 23 different sites in 15 countries. Results: Herein, we detail the allele frequencies for the novel risk factors (p.A419V and p.M1646T) and the protective haplotype (p.N551K-R1398H-K1423K) nominated in the original publication. Simple population allele frequencies not only can provide insight into the clinical relevance of specific variants but also can help genetically define patient groups. Conclusions: Establishing individual patient-based genomic susceptibility profiles that incorporate both risk factors and protective factors will determine future diagnostic and treatment strategies. © 2013 Movement Disorder Society.
Authors & Co-Authors
Heckman, Michael G.
Unknown Affiliation
Soto-Ortolaza, Alexandra I.
Unknown Affiliation
Aasly, Jan Olav
Unknown Affiliation
Abahuni, Nadine
Unknown Affiliation
Annesi, Grazia
Unknown Affiliation
Bacon, Justin A.
Unknown Affiliation
Bardien, Soraya
Unknown Affiliation
Bozi, Maria
Unknown Affiliation
Brice, Alexis
Unknown Affiliation
Brighina, Laura
Unknown Affiliation
Carr, Jonathan A.
Unknown Affiliation
Chartier-Harlin, Marie Christine
Unknown Affiliation
Dardiotis, Efthymios
Unknown Affiliation
Dickson, Dennis W.
Unknown Affiliation
Diehl, Nancy N.
Unknown Affiliation
Elbaz, Alexis
Unknown Affiliation
Ferrarese, Carlo
Unknown Affiliation
Fiske, Brian K.
Unknown Affiliation
Gibson, J. Mark
Unknown Affiliation
Gibson, Rachel A.
Unknown Affiliation
Hadjigeorgiou, Georgios M.
Unknown Affiliation
Hattori, Nobutaka
Unknown Affiliation
Ioannidis, John P.A.
Unknown Affiliation
Boczarska-Jedynak, Magdalena
Unknown Affiliation
Jasińska-Myga, Barbara
Unknown Affiliation
Jeon, Beomseok
Unknown Affiliation
Kim, Yunjoong
Unknown Affiliation
Klein, Christine
Unknown Affiliation
Krüger, Rejko
Unknown Affiliation
Kyratzi, Elli
Unknown Affiliation
Lesage, Suzanne
Unknown Affiliation
Lin, Chinhsien
Unknown Affiliation
Lynch, Timothy L.
Unknown Affiliation
Maraganore, Demetrius M.
Unknown Affiliation
Mellick, George D.
Unknown Affiliation
Mutez, Eugénie
Unknown Affiliation
Nilsson, Christer
Unknown Affiliation
Opala, Grzegorz M.
Unknown Affiliation
Park, Sungsup
Unknown Affiliation
Petrucci, Simona
Unknown Affiliation
Puschmann, Andreas J.
Unknown Affiliation
Quattrone, Aldo
Unknown Affiliation
Sharma, Manu
Unknown Affiliation
Silburn, Peter A.S.
Unknown Affiliation
Sohn, Young Ho
Unknown Affiliation
Stefanis, Leonidas
Unknown Affiliation
Tadic, Vera
Unknown Affiliation
Theuns, Jessie
Unknown Affiliation
Tomiyama, Hiroyuki
Unknown Affiliation
Uitti, Ryan J.
Unknown Affiliation
Valente, Enza Maria
Unknown Affiliation
van Broeckhoven, Christine L.
Unknown Affiliation
van de Loo, Simone
Unknown Affiliation
Vassilatis, Demetrios K.
Unknown Affiliation
Vilarino-Guell, Carles
Unknown Affiliation
White, Linda R.
Unknown Affiliation
Wirdefeldt, Karin
Unknown Affiliation
Wszołek, Zbigniew K.
Unknown Affiliation
Wu, Ruey Meei
Unknown Affiliation
Hentati, F. F.
Unknown Affiliation
Farrer, Matthew J.
Unknown Affiliation
Ross, Owen A.
Unknown Affiliation
Statistics
Citations: 62
Authors: 62
Affiliations: 44
Identifiers
Doi:
10.1002/mds.25600
ISSN:
08853185
e-ISSN:
15318257
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study