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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Breast-milk shedding of drug-resistant HIV-1 subtype C in women exposed to single-dose nevirapine
Journal of Infectious Diseases, Volume 192, No. 7, Year 2005
Notification
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Description
Single-dose nevirapine reduces intrapartum human immunodeficiency virus 1 type (HIV-1) transmission but may also select for nonnucleoside reverse-transcriptase inhibitor (NNRTI) resistance in breast milk (BM) and plasma. Among 32 Zimbabwean women, median 8-week postpartum plasma and BM HIV-1 RNA levels were 4.57 and 2.13 log10 copies/ mL, respectively. BM samples from women with laboratory-diagnosed mastitis (defined as elevated BM Na+ levels) were 5.4-fold more likely to have HIV-1 RNA levels above the median. BM RT sequences were not obtained for 12 women with BM HIV-1 RNA levels below the lower limit of detection of the assay used. In 20 paired BM and plasma samples, 65% of BM and 50% of plasma RT sequences had NNRTI-resistance mutations, with divergent mutation patterns. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Lee, Esther J.
United States, Stanford
Stanford University School of Medicine
Kantor, Rami
United States, Stanford
Stanford University School of Medicine
Zijenah, Lynn Sodai
Zimbabwe, Harare
University of Zimbabwe
Sheldon, Wayne
United States, Seattle
Fred Hutchinson Cancer Research Center
Emel, Lynda Marie
United States, Seattle
Fred Hutchinson Cancer Research Center
Mateta, Patrick
Zimbabwe, Harare
University of Zimbabwe
Johnston, Elizabeth R.
United States, Stanford
Stanford University School of Medicine
Wells, Jennifer
Zimbabwe, Harare
University of Zimbabwe
Shetty, Avinash K.
Zimbabwe, Harare
University of Zimbabwe
Coovadia, Hoosen Mahomed
South Africa, Durban
The Nelson R. Mandela Medical School
Maldonado, Yvonne Aida
United States, Stanford
Stanford University School of Medicine
Jones, Samuel Adeniyi
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Mofenson, Lynne M.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Contag, Christopher H.
United States, Stanford
Stanford University School of Medicine
Bassett, Mary Travis
Zimbabwe, Harare
University of Zimbabwe
Katzenstein, David A.
United States, Stanford
Stanford University School of Medicine
Statistics
Citations: 73
Authors: 16
Affiliations: 6
Identifiers
Doi:
10.1086/444424
ISSN:
00221899
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Participants Gender
Female