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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HCV-related morbidity in a rural community of Egypt
Journal of Medical Virology, Volume 78, No. 9, Year 2006
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Description
The origin of the hepatitis C virus (HCV) epidemic in Egypt has been attributed to intravenous schistosomiasis treatment in rural areas in the 1960s to 70s. The objective of this study was to estimate the HCV-related morbidity in a rural area where mass schistosomiasis treatment campaigns took place 20-40 years before. The study sample included 2,425 village residents aged 18-65 years recruited through home-based visits. Overall, HCV antibody prevalence was 448/2,425 = 18.5% (95% CI = 16.9-20.1%), reaching 45% in males over 40 years, and 30% in females over 50 years. Of those with HCV antibodies, 284/448 (63.4%, 95% CI = 58.7-67.9%) had chronic HCV infection, among which 107/266 (40.2%, 95% CI = 34.3-46.4%) had elevated alanine amino-transferase (ALT). As part of pre-treatment screening, 26 consenting patients had a liver biopsy: 13 (50.0%) had a treatment indication. Thus, of all patients with HCV antibodies, 13 (2.9%) were eligible for treatment and willing to be treated. The relatively low level of morbidity observed in this study is discussed in view of co-factors of HCV infection progression, such as young age at infection, absence of alcohol intake, the prevalence of Schistosoma mansoni infection, and the prevalence of chronic hepatitis B. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Mohamed, Mostafa K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Bakr, Iman M.A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
El-Hoseiny, Mostafa M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Arafa, Naglaa A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Hassan, Abubakr
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Ismail, Sohier Ahmed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Anwar, Mohamed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Attala, Mohamed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Rekacewicz, Claire
France, Paris
Institut Pasteur, Paris
Zalata, Khaled Refaat
Egypt, Mansoura
Faculty of Medicine
Abdel-Hamid, Mohamed A.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Egypt, Minya
Faculty of Medicine
Esmat, Gamal
Egypt, Cairo
Faculty of Medicine
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 47
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1002/jmv.20679
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Infectious Diseases
Substance Abuse
Study Design
Cross Sectional Study
Study Locations
Egypt
Participants Gender
Female