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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Anti-inflammatory and immunosuppressive effects of the enaminone E121
European Journal of Pharmacology, Volume 632, No. 1-3, Year 2010
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Description
Asthma is a chronic inflammatory disease of the airways. The treatment of asthma is far from optimal and hence the need for novel therapeutic agents exists. The purpose of this study was to assess the anti-asthma effects of an enaminone, E121, and also its effects on human peripheral blood mononuclear cell proliferation and cytokine release. The effects of E121 were assessed in an ovalbumin-induced model of airway inflammation and airway hyperresponsiveness. In addition, the effects of E121 on phytohemagglutinin (PHA), anti-CD3 monoclonal antibody and lipopolysaccharide (LPS)-induced human peripheral blood mononuclear cell proliferation and cytokine release, respectively, were assessed. Treatment of mice with E121 significantly decreased the ovalbumin-induced increase in airway total cell influx and eosinophil infiltration and this was associated with an inhibition of ovalbumin-induced airway hyperresponsiveness. Moreover, E121 reduced PHA and anti-CD3-induced human peripheral blood mononuclear cell proliferation in vitro. E121 also inhibited PHA, anti-CD3 monoclonal antibody and LPS-induced cytokine release from human peripheral blood mononuclear cell cultures. These findings indicate that E121 exhibits anti-inflammatory and immunosuppressive activities. © 2009 Elsevier B.V. All rights reserved.
Authors & Co-Authors
El-Hashim, Ahmed Z.
Kuwait, Kuwait City
Kuwait University
Yousefi, Shida
Switzerland, Bern
University of Bern
Edafiogho, Ivan Ogheneochuko
Kuwait, Kuwait City
Kuwait University
Raghupathy, Raj Gopal
Kuwait, Kuwait City
Kuwait University
Yousif, Mariam H.M.
Kuwait, Kuwait City
Kuwait University
Simon, H. U.
Switzerland, Bern
University of Bern
Statistics
Citations: 24
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejphar.2009.12.004
ISSN:
00142999