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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
The burden attributable to mental and substance use disorders as risk factors for suicide: Findings from the Global Burden of Disease Study 2010
PLoS ONE, Volume 9, No. 4, Article e91936, Year 2014
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Description
Background: The Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the increased risk of suicide captured elsewhere in GBD 2010's mutually exclusive list of diseases and injuries. Here, we estimate suicide DALYs attributable to mental and substance use disorders. Methods: Relative-risk estimates of suicide due to mental and substance use disorders and the global prevalence of each disorder were used to estimate population attributable fractions. These were adjusted for global differences in the proportion of suicide due to mental and substance use disorders compared to other causes then multiplied by suicide DALYs reported in GBD 2010 to estimate attributable DALYs (with 95% uncertainty). Results: Mental and substance use disorders were responsible for 22.5 million (14.8-29.8 million) of the 36.2 million (26.5-44.3 million) DALYs allocated to suicide in 2010. Depression was responsible for the largest proportion of suicide DALYs (46.1% (28.0%-60.8%)) and anorexia nervosa the lowest (0.2% (0.02%-0.5%)). DALYs occurred throughout the lifespan, with the largest proportion found in Eastern Europe and Asia, and males aged 20-30 years. The inclusion of attributable suicide DALYs would have increased the overall burden of mental and substance use disorders (assigned to them in GBD 2010 as a direct cause) from 7.4% (6.2%-8.6%) to 8.3% (7.1%-9.6%) of global DALYs, and would have changed the global ranking from 5th to 3rd leading cause of burden. Conclusions: Capturing the suicide burden attributable to mental and substance use disorders allows for more accurate estimates of burden. More consideration needs to be given to interventions targeted to populations with, or at risk for, mental and substance use disorders as an effective strategy for suicide prevention. © 2014 Ferrari et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3973668/bin/pone.0091936.s001.zip
Authors & Co-Authors
Ferrari, Alize J.
Australia, Brisbane
The University of Queensland
Pacella, Rosana
Australia, Brisbane
The University of Queensland
Freedman, Greg D.
United States, Seattle
Institute for Health Metrics and Evaluation
Baxter, Amanda J.
Australia, Brisbane
The University of Queensland
Pirkis, Jane Elizabeth
Australia, Melbourne
University of Melbourne
Harris, Meredith G.
Australia, Brisbane
The University of Queensland
Page, Andrew Nicolas
Australia, Penrith
Western Sydney University
Carnahan, Emily
United States, Seattle
Institute for Health Metrics and Evaluation
Degenhardt, Louisa
Australia, Melbourne
University of Melbourne
Australia, Sydney
Unsw Sydney
Vos, Theo
Australia, Brisbane
The University of Queensland
United States, Seattle
Institute for Health Metrics and Evaluation
Whiteford, Harvey A.
Australia, Brisbane
The University of Queensland
Statistics
Citations: 315
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0091936
ISSN:
19326203
Research Areas
Disability
Mental Health
Substance Abuse
Violence And Injury
Study Design
Cross Sectional Study