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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial
Journal of Infectious Diseases, Volume 209, No. 12, Year 2014
Notification
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Description
The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated that vaginally applied tenofovir gel is a promising intervention for protecting women from sexually acquiring human immunodeficiency virus (HIV). However, the potential for emergence of tenofovir resistance remains a concern in women who seroconvert while using the gel despite the lack of plasma virus resistance as assessed by population sequencing during the trial. We applied highly sensitive polymerase chain reaction-based assays to screen for tenofovir resistance in plasma and vaginal swab specimens. The absence of mutation detection suggested little immediate risk of tenofovir-resistant HIV-1 emergence and forward transmission in settings in which gel users are closely monitored for HIV seroconversion. © 2014 Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4038144/bin/supp_209_12_1916__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4038144/bin/supp_jiu026_jiu026supp.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4038144/bin/supp_jiu026_jiu026supp_table.docx
Authors & Co-Authors
Wei, Xierong
United States, Atlanta
Centers for Disease Control and Prevention
Hunt, Gillian M.
United States
National Inst for Communicable Diseases
Abdool Karim, Salim S.
United States, New York
Columbia University
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Naranbhai, Vivek
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Sibeko, Sengeziwe Sibongile
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Abdool Karim, Quarraisha Abdool
United States, New York
Columbia University
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Li, Jin Fen
United States, Atlanta
Centers for Disease Control and Prevention
Kashuba, Angela D.M.
United States, Chapel Hill
Unc Eshelman School of Pharmacy
Werner, Lise
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Passmore, Jo Ann Shelley
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Morris, Lynn
United States
National Inst for Communicable Diseases
Heneine, Walid
United States, Atlanta
Centers for Disease Control and Prevention
Johnson, Jeffrey A.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 16
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1093/infdis/jiu026
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Cancer
Infectious Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
South Africa
Participants Gender
Female