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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antioxidants and electrolyte profile in early pregnancy: In vivo studies
American Journal of Biochemistry and Molecular Biology, Volume 1, No. 1, Year 2011
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Description
The effect on electrolyte profile following oral administration of antioxidants (vitamin A, C and E supplements in early pregnancy was investigated using albino rats of the Wistar strain. Eighty-five female rats weighing between 255-300 g were used for the study. They were randomly assigned to three study groups having 5 sub groups with five animals each, a control and vehicle group with five animals each. After pregnancy has been confirmed, the control group was administered 1 mL of distilled water, vehicle group 1 mL of tween 80, while test groups 1, II and III received different doses of vitamin A, C and E, respectively via the intragastric route for 11 days. The administration of vitamin A, C and E in early pregnancy for 11 days produced insignificant changes in serum Na+ levels (p>0.05) and a significant increase in serum Ca2+ level. With the exception of vitamin C, vitamin A and E produce a significant increase in serum K+ and Cl- levels. Conclusively administration of vitamin A, C and E in early pregnancy cause no significant alteration in serum Na+ levels. However, care must be taken when vitamin A and E are administered with agents that elevate serum Ca2+ and K+ levels as this may pontentiate hypercalcemia and hyperkalemia, respectively in early pregnancy. © 2011 Academic Journals Inc.
Authors & Co-Authors
Iribhogbe, Osede Ignis
Nigeria, Ekpoma
Ambrose Alli University
Akpamu, Uwaifoh
Nigeria, Ekpoma
Ambrose Alli University
Emordi, Jonathan E.
Nigeria, Ekpoma
Ambrose Alli University
Aigbiremolen, A. E.
Nigeria, Ekpoma
Ambrose Alli University
Nwoke, E. O.
Nigeria, Ekpoma
Ambrose Alli University
Idinoje, B.
Nigeria, Ekpoma
Ambrose Alli University
Statistics
Citations: 8
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.3923/ajbmb.2011.82.88
e-ISSN:
21504253
Research Areas
Environmental
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Participants Gender
Female