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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
EFFECTIVENESS OF AMODIAQUINE AS TREATMENT FOR CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM INFECTIONS IN KENYA
The Lancet, Volume 323, No. 8373, Year 1984
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Description
Studies were conducted in Malindi, Kenya, to assess the response of Plasmodium falciparum to chloroquine and amodiaquine in vivo (by an extended 14-day test) and in vitro (with the Rieckmann micro test). In-vivo resistance was demonstrated in 19 of 69 (28%) infections treated with chloroquine, but in only 2 of 60 (3·3%) of those treated with amodiaquine (p<0·001). In-vitro resistance to chloroquine was demonstrated in 15 of 23 (65%) tests. In contrast, 22 of the same 23 isolates were sensitive to amodiaquine in vitro. Effective concentrations by probit analysis for 50% and 99% (EC50 and EC99) inhibition, respectively, were 180·7 and 4319·6 nmol/l for chloroquine and 12·2 and 147·0 nmol/l for amodiaquine. The results suggest that amodiaquine is effective for the treatment of chloroquine-resistant falciparum malaria in Kenya. © 1984.
Authors & Co-Authors
Watkins, Williams M.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
United States, Atlanta
National Center for Infectious Diseases
United Kingdom
Kenya Ministry of Health
Spencer, Harrison C.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
United States, Atlanta
National Center for Infectious Diseases
United Kingdom
Kenya Ministry of Health
Kariuki, Daniel M.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
United States, Atlanta
National Center for Infectious Diseases
United Kingdom
Kenya Ministry of Health
Sixsmith, David G.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
United States, Atlanta
National Center for Infectious Diseases
United Kingdom
Kenya Ministry of Health
Boriga, David A.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
United States, Atlanta
National Center for Infectious Diseases
United Kingdom
Kenya Ministry of Health
Kipingor, Tamara
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
United States, Atlanta
National Center for Infectious Diseases
United Kingdom
Kenya Ministry of Health
Koech, David Kiprotich
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
United States, Atlanta
National Center for Infectious Diseases
United Kingdom
Kenya Ministry of Health
Statistics
Citations: 139
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/S0140-6736(84)90410-0
ISSN:
01406736
Research Areas
Infectious Diseases
Study Locations
Kenya