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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effects of plasma treatment to nanofibers on initial cell adhesion and cell morphology
Colloids and Surfaces B: Biointerfaces, Volume 113, Year 2014
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Description
Poly-l-lactic acid (PLLA) nanofibers were fabricated by electrospinning and treated with O2 plasma. The surface properties of PLLA nanofibers before and after plasma treatment were characterized by water contact angle measurement and X-ray photoelectron spectroscopy (XPS). It was found that the hydrophilicity of PLLA nanofibers was improved and the amount of oxygen-containing groups increased after plasma treatment. Initial cell adhesion was evaluated by cell capture efficiency based on the cell count method. The results showed that initial porcine mesenchymal stem cells (pMSCs) adhesion to plasma-treated nanofibers was significantly enhanced. Moreover, the morphology of pMSCs on PLLA nanofibers (PLLA NFS) and plasma-treated PLLA nanofibers (P-PLLA NFS) were observed by scanning electron microscope (SEM) after 10min, 20min, 30min and 60min cell adhesion. It was found that plasma treatment to electrospun nanofibers had a great effect on pMSCs morphology at earlier time points. Therefore, plasma treatment is an efficient surface modification strategy to improve cell adhesion in earlier culture time intervals. It may be a promising method in the design of novel tissue-engineered scaffolds. © 2013 Elsevier B.V.
Authors & Co-Authors
Liu, Wei
China, Shanghai
Donghua University
Zhan, Jianchao
China, Shanghai
Donghua University
China, Jiaxing
Jiaxing University
Su, Yan
China, Shanghai
Donghua University
Wu, Tong
China, Shanghai
Donghua University
Wu, Chunchen
China, Shanghai
Donghua University
Ramakrishna, Seeram A.
Singapore, Singapore City
National University of Singapore
Mo, Xiumei
China, Shanghai
Donghua University
Al-Deyab, Salem Salem
Saudi Arabia, Riyadh
College of Sciences
El-Newehy, Mohamed Hassan
Saudi Arabia, Riyadh
College of Sciences
Egypt, Tanta
Faculty of Science
Statistics
Citations: 94
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.colsurfb.2013.08.031
ISSN:
09277765
e-ISSN:
18734367
Research Areas
Cancer
Environmental