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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Oncogenic viral prevalence in invasive vulvar cancer specimens from human immunodeficiency virus-positive and -negative women in botswana
International Journal of Gynecological Cancer, Volume 24, No. 4, Year 2014
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Description
Objective: The primary aim of this study was to describe the prevalence of select oncogenic viruses within vulvar squamous cell carcinoma (VSCC) and their association with human immunodeficiency virus (HIV) status in women in Botswana, where the national HIV prevalence is the third highest in the world. Methods: A cross-sectional study of biopsy-confirmed VSCC specimens and corresponding clinical data was conducted in Gaborone, Botswana. Polymerase chain reaction (PCR) and immunohistochemistry (IHC) viral testing were done for Epstein-Barr virus, human papillomavirus (HPV) strains, and Kaposi sarcoma herpesvirus, and PCR viral testing alone was done for John Cunningham virus. Results: Human papillomavirus prevalence by PCR was 100% (35/35) among tested samples. Human papillomavirus type 16was the most prevalent HPV strain (82.9%by PCR, 94.7% by either PCR or IHC). Kaposi sarcoma herpesvirus prevalence by PCR had a significant association with HIV status (P = 0.013), but not by IHC (P = 0.650). Conclusions: The high burden of HPV, specifically HPV16, in vulvar squamous cell cancer in Botswana suggests a distinct HPV profile that differs from other studied populations, which provides increasedmotivation for HPV vaccination efforts. Oncogenic viruses Kaposi sarcoma herpes virus and Epstein-Barr virus were also more prevalent in our study population, although their potential role in vulvar squamous cell cancer pathology is unclear. Copyright © 2014 by IGCS and ESGO.
Authors & Co-Authors
Tesfalul, Martha A.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
United States, Philadelphia
Botswana-upenn Partnership
Simbiri, Kenneth Omollo A.
United States, Philadelphia
University of Pennsylvania
Wheat, Chikoti M.
United States, Philadelphia
Botswana-upenn Partnership
United States, Durham
Duke University School of Medicine
Motsepe, Didintle
Botswana, Gaborone
Princess Marina Hospital
Goldbach, Hayley S.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Armstrong, Kathleen Anne
Canada, Toronto
University of Toronto
Hudson, Kathryn
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Kayembe, Mukendi K.A.
Botswana, Gaborone
Botswana National Health Laboratory
Robertson, Erle S.
United States, Philadelphia
University of Pennsylvania
Kovarik, Carrie Lynn
United States, Philadelphia
Botswana-upenn Partnership
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Statistics
Citations: 12
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1097/IGC.0000000000000111
ISSN:
1048891X
e-ISSN:
15251438
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Botswana
Participants Gender
Female