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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effectiveness of rifaximin and fluoroquinolones in preventing travelers' diarrhea (TD): A systematic review and meta-analysis
Systematic Reviews, Volume 1, No. 1, Article 39, Year 2009
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Description
Background: Recent developments related to a safe and effective nonabsorbable antibiotic, rifaximin, and identification of postinfectious irritable bowel syndrome as a frequent sequela call for a need to reconsider the value of primary prevention of traveler's diarrhea (TD) with antibiotics.Methods: Randomized, placebo-controlled, double-blind studies evaluating the effectiveness and safety of rifaximin or a fluoroquinolone chemoprophylaxis against TD were pooled using a random effects model and assessed for heterogeneity.Results: The nine studies (four rifaximin and five fluoroquinolone) included resulted in pooled relative risk estimates of 0.33 (95% CI = 0.24-0.45, I2 = 3.1%) and 0.12 (95% CI = 0.07-0.20, I2 =0.0%), respectively. Similar rates of treatment emergent adverse events were found between antibiotic and placebo groups.Conclusions: This meta-analysis supports the effectiveness of antibiotics in preventing TD. However, further studies that include prevention of secondary chronic health outcomes among travelers to different geographic regions, and a formal risk-benefit analysis for antibiotic chemoprophylaxis, are needed. © 2012 Alajbegovic et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Sanders, John Walton
United States, Silver Spring
Naval Medical Research Center
Atherly, Deborah E.
United States, Seattle
Path Seattle
Riddle, Mark S.
United States, Silver Spring
Naval Medical Research Center
Statistics
Citations: 32
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1186/2046-4053-1-39
ISSN:
20464053
Research Areas
Disability
Genetics And Genomics
Study Approach
Systematic review