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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HLA-DQ types of celiac disease in Libyan children with type 1 diabetes mellitus
European Journal of Gastroenterology and Hepatology, Volume 24, No. 1, Year 2012
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Description
OBJECTIVE: To determine the genetic profile of celiac disease (CD) in Libyan children with type 1 diabetes as there are no data on the frequency of human leukocyte antigen (HLA)-related CD-predisposing genes in diabetic patients in Libya. METHODS: We randomly studied 218 Libyan type 1 diabetic children. The mean age was 12.2±4.6 years; 56% were female patients. The mean duration of diabetes was 4.7±4.0 years. All patients were screened for CD with IgA tissue-transglutaminase (tTG) and endomysium antibodies. Patients with positive immunological screen were programmed for a small-bowel biopsy. HLA-DRB1* and HLA-DQB1* were genotyped in all tTG-positive patients. RESULTS: Twenty-seven (12.4%) out of 218 patients with type1 diabetes had positive tTG, and 20 (9.2%) of these patients were positive for endomysium antibodies. Five patients (5/27) were already known cases of biopsy-proven CD. Biopsy was not performed in two patients. One biopsy result was normal, whereas 19 biopsies demonstrated morphological changes consistent with CD. Forty-eight percent of the anti-tTG-positive group were homozygous for HLA-DQ2, whereas 75% of biopsy-proven CD patients had HLA-DQ2, 21% had HLA-DQ2/DQ8, and 4% had HLA-DQ8. In addition, the majority (70%) carried HLA-DQ2 linkage with HLA-DRB1*03. CONCLUSION: Overall, biopsy-confirmed prevalence of CD was 11% (24 of 218). The present study confirms that CD in the Libyan type 1 diabetic population is high when compared with European and US studies, and for the first time we document that this population shares similar HLA-DQ2 genotype. This supports the theory regarding the role of the environment as an important factor in CD development in this part of the world. © 2012 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Ghawil, Millad
Italy, Udine
Università Degli Studi Di Udine
Miotti, Valeria
Italy, Udine
Genetic and Blood Transfusion Department
Tonutti, Elio
Italy, Udine
Policlinico Universitario, Udine
Tenore, Alfred
Italy, Udine
Università Degli Studi Di Udine
Hadeed, Ibtisam
Libya, Tripoli
Tripoli Medical Center
Sindici, Chiara
Italy, Udine
Genetic and Blood Transfusion Department
Visentini, Daniela
Italy, Udine
Policlinico Universitario, Udine
Morgham, Amel
Libya, Tripoli
University of Tripoli
Abusrewil, Sulieman
Libya, Tripoli
Tripoli Medical Center
Statistics
Citations: 19
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1097/MEG.0b013e32834d09d4
ISSN:
0954691X
e-ISSN:
14735687
Research Areas
Genetics And Genomics
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Libya
Participants Gender
Female