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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males
Vaccine, Volume 31, No. 37, Year 2013
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Description
A small number of HPV types are related to a majority of HPV-related neoplastic lesions in humans. High-risk types such as HPV 16 and 18 are most often implicated, although other oncogenic and non-oncogenic HPV types can cause disease in men. The efficacy of the quadrivalent HPV vaccine (qHPV) against external genital lesions and intra-anal disease related to HPV in men has been demonstrated. This report examines the vaccine's efficacy against disease due to 10 additional non-vaccine HPV types, as well as efficacy regardless of HPV detection. The data presented suggest that vaccinating males against HPV 6, 11, 16 and 18 protects them against most vaccine HPV-type related anogenital disease. However, significant efficacy against disease due to non-vaccine HPV types was not seen. In addition, the data do not provide any evidence that vaccination with qHPV vaccine will increase the likelihood of disease caused by non-vaccine types in the short term. © 2013 Elsevier Ltd.
Authors & Co-Authors
Goldstone, Stephen E.
Unknown Affiliation
Jessen, Heiko K.
Unknown Affiliation
Palefsky, Joel Michael
Unknown Affiliation
Giuliano, Anna Regina
Unknown Affiliation
Duarte Moreira, Edson Duarte
Unknown Affiliation
Vardas, Eftyhia
Unknown Affiliation
Aranda, Carlos
Unknown Affiliation
Hillman, Richard John
Unknown Affiliation
Ferris, Daron G.
Unknown Affiliation
Coutlée, François
Unknown Affiliation
Marshall, J. Brooke
Unknown Affiliation
Vuocolo, Scott
Unknown Affiliation
Haupt, Richard M.
Unknown Affiliation
Güriş, Dalya
Unknown Affiliation
Garner, Elizabeth I.O.
Unknown Affiliation
Statistics
Citations: 51
Authors: 15
Affiliations: 13
Identifiers
Doi:
10.1016/j.vaccine.2013.06.057
ISSN:
0264410X
e-ISSN:
18732518
Research Areas
Cancer
Sexual And Reproductive Health
Participants Gender
Male