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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Discovery of diverse polyomaviruses in bats and the evolutionary history of the Polyomaviridae
Journal of General Virology, Volume 94, No. PART4, Year 2013
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Description
Polyomaviruses (PyVs) have been identified in a wide range of avian and mammalian species. However, little is known about their occurrence, genetic diversity and evolutionary history in bats, even though bats are important reservoirs for many emerging viral pathogens. This study screened 380 specimens from 35 bat species from Kenya and Guatemala for the presence of PyVs by semi-nested pan-PyV PCR assays. PyV DNA was detected in 24 of the 380 bat specimens. Phylogenetic analysis revealed that the bat PyV sequences formed 12 distinct lineages. Fullgenome sequences were obtained for seven representative lineages and possessed similar genomic features to known PyVs. Strikingly, this evolutionary analysis revealed that the bat PyVs were paraphyletic, suggestive of multiple species jumps between bats and other mammalian species, such that the theory of virus-host co-divergence for mammalian PyVs as a whole could be rejected. In addition, evidence was found for strong heterogeneity in evolutionary rate and potential recombination in a number of PyV complete genomes, which complicates both phylogenetic analysis and virus classification. In summary, this study revealed that bats are important reservoirs of PyVs and that these viruses have a complex evolutionary history. © 2013 SGM.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC7346582/bin/jgv-94-738-s001.pdf
Authors & Co-Authors
Tao, Ying
United States, Atlanta
Centers for Disease Control and Prevention
Shi, Mang
Australia, Sydney
The University of Sydney School of Medicine
Conrardy, Christina
United States, Atlanta
Centers for Disease Control and Prevention
Kuzmin, Ivan V.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Recuenco, Sergio E.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Agwanda, Bernard Risky
Kenya, Nairobi
Kenya Wildlife Service
Alvarez, Danilo
Guatemala, Guatemala City
Universidad Del Valle de Guatemala
Ellison, James A.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Gilbert, Amy T.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Morán, David
Guatemala, Guatemala City
Universidad Del Valle de Guatemala
Niezgoda, Michael
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Lindblade, Kim A.
United States, Atlanta
Centers for Disease Control and Prevention
Holmes, Edward C.
Australia, Sydney
The University of Sydney School of Medicine
United States, Bethesda
Fogarty International Center
Breiman, Robert F.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Rupprecht, Charles E.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Tong, Suxiang Sue
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 61
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.1099/vir.0.047928-0
ISSN:
00221317
e-ISSN:
14652099
Research Areas
Genetics And Genomics
Study Locations
Kenya