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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a ghanaian community
International Journal of Women's Health, Volume 6, No. 1, Year 2014
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Description
Background: Hormonal contraceptives (HCs) have been shown to alter lipid profile among various population groups with different patterns of dyslipidemia and cardiovascular (CV) risk. The study aimed at determining the lipid profile pattern and CV risk in a Ghanaian cohort. Methods: Purposive random sampling was done. Forty-seven and 19 cases were on oral contraceptives (OCs) and injectable contraceptives (ICs), respectively; five were on subdermal implant. Twenty-four non-users served as controls. Biodemographic and lipid profiles were determined. Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), and very-low-density lipid lipoprotein cholesterol (VLDLC), were determined. Castelli index I and II were calculated. Results: The mean age difference between the HC and control groups was insignificant. However, diastolic blood pressure (BP) differences were significant (P=0.006). The body mass index (BMI) of the OC and IC groups were significantly different from the control group (P=0.003 and P=0.008, respectively). TC levels for the control and case groups were 3.35±0.62 mmol/L and 4.07±0.91 mmol/L, respectively (P=0.002). LDLC levels for the control and case groups were 1.74±0.57 mmol/L and 2.38±0.84 mmol/L, respectively (P=0.003). Castelli index I (TC/HDLC) and II (LDLC/HDLC) were significantly different between the control and OC groups (P=0.026 and P=0.014, respectively). Spearman's rho correlation showed significant influence of HC use on TG (P=0.026), TC (P=0.000), LDLC (P=0.004), and VLDLC (P=0.026) over time. Conclusion: HC use is associated with significant increases in BMI, diastolic BP, TC, LDLC, and Castelli index I and II. These changes carry a potential risk in the development of CV disease. © 2014 Asare et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4051713/bin/IJWH-6-597-s.avi
Authors & Co-Authors
Asare, George Awuku
Unknown Affiliation
Santa, Sheila A.
Unknown Affiliation
Angala, Robert A.
Unknown Affiliation
Asiedu, Bernice
Unknown Affiliation
Afriyie, Daniel Kwame
Unknown Affiliation
Amoah, Albert Gb
Unknown Affiliation
Statistics
Citations: 60
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.2147/IJWH.S59852
e-ISSN:
11791411
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study