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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Estimating modifiable coronary heart disease risk in multiple regions of the world: The INTERHEART Modifiable Risk Score
European Heart Journal, Volume 32, No. 5, Year 2011
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Description
Aims Summating risk factor burden is a useful approach in the assessment of cardiovascular risk among apparently healthy individuals. We aimed to derive and validate a new score for myocardial infarction (MI) risk using modifiable risk factors, derived from the INTERHEART casecontrol study (n=19 470). Methods and results Multiple logistic regression was used to create the INTERHEART Modifiable Risk Score (IHMRS). Internal validation was performed using split-sample methods. External validation was performed in an international prospective cohort study. A risk model including apolipoproteins, smoking, second-hand smoke exposure, hypertension, and diabetes was developed. Addition of further modifiable risk factors did not improve score discrimination in an external cohort. Split-sample validation studies showed an area under the receiver-operating characteristic (ROC) curve c-statistic of 0.71 [95 confidence interval (CI): 0.70, 0.72]. The IHMRS was positively associated with incident MI in a large cohort of people at low risk for cardiovascular disease [12 increase in MI risk (95 CI: 8, 16) with a 1-point increase in score] and showed appropriate discrimination in this cohort (ROC c-statistic 0.69, 95 CI: 0.64, 0.74). Results were consistent across ethnic groups and geographic regions. A non-laboratory-based score is also supplied. Conclusions Using multiple modifiable risk factors from the INTERHEART casecontrol study, we have developed and validated a simple score for MI risk which is applicable to an international population. © 2010 The Author.
Authors & Co-Authors
McGorrian, Catherine M.
Canada, Hamilton
Population Health Research Institute, Ontario
Ireland, Dublin
University College Dublin
Yusuf, Salim N.
Canada, Hamilton
Population Health Research Institute, Ontario
Islam, Shofiqul
Canada, Hamilton
Population Health Research Institute, Ontario
Jung, Hyejung
Canada, Hamilton
Population Health Research Institute, Ontario
Rangarajan, Sumathy
Canada, Hamilton
Population Health Research Institute, Ontario
Avezum, Álvaro Jr
Brazil, Sao Paulo
Instituto Dante Pazzanese de Cardiologia
Prabhakaran, Dorairaj
India, New Delhi
Centre for Chronic Disease Control
Al-Mahmeed, Wael Abdulrahman R.
United Arab Emirates, Abu Dhabi
Sheikh Khalifa Medical City
Rumboldt, Zvonko
Croatia, Split
School of Medicine, University of Split
Budaj, Andrzej J.
Poland, Warsaw
Szpital Grochowski, Warszawa
Dans, Antonio L.L.
Philippines, Manila
University of the Philippines Manila
Gerstein, Hertzel C.
Canada, Hamilton
Population Health Research Institute, Ontario
Teo, Koonkang
Canada, Hamilton
Population Health Research Institute, Ontario
Anand, Sonia S.
Canada, Hamilton
Population Health Research Institute, Ontario
Statistics
Citations: 233
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1093/eurheartj/ehq448
ISSN:
0195668X
e-ISSN:
15229645
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Multi-countries