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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Human Papillomavirus type distribution in invasive cervical cancer in Uganda
BMC Infectious Diseases, Volume 8, Article 85, Year 2008
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Description
Background: We conducted a study aiming to describe Human Papillomavirus (HPV) type distribution in invasive cervical carcinoma in Uganda. Methods: 191 archival cervical carcinoma samples diagnosed in the Department of Pathology, Makerere University in Kampala between 1968 and 1992 were analysed using a sensitive PCR-Reverse Hybridization Line Probe Assay. Results: Out of the 186 cases of confirmed invasive cervical cancer in the study paraffin blocks, 114 were positive for HPV DNA. Specific HPV genotypes were identifiable in 109 cases: HPV 16, 18, 31, 35, 39, 44, 45, 51, 52 and 70. These occurred as single infections in 105 cases (96.3%) and as multiple infections in 4 cases (3.7%). HPV 16 or 18 accounted for 80% (84/105) of cases with single infection. Conclusion: The results of this study confirm the role of HPV 16 and 18 in cervical cancer pathogenesis in the Ugandan population. The results suggest that the currently available HPV vaccines against HPV 16 and 18 could possibly prevent the majority of invasive cervical cancers in Uganda. © 2008 Odida et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Odida, Michael
Uganda, Kampala
Makerere University
Sweden, Stockholm
Karolinska Institutet
de Sanjosé, Sílvia
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Quint, Wim G.V.
Netherlands, Voorburg
Ddl Diagnostic Laboratory
Bosch, Francisco Xavier
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Klaustermeier, Jo Ellen
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Weiderpass, Elisabete
Sweden, Stockholm
Karolinska Institutet
Norway, Tromso
Uit Norges Arktiske Universitet
Statistics
Citations: 47
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2334-8-85
e-ISSN:
14712334
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Uganda