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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Distinct expression profiles of TGF-β1 signaling mediators in pathogenic SIVmac and non-pathogenic SIVagm infections
Retrovirology, Volume 3, Article 37, Year 2006
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Description
Background: The generalized T-cell activation characterizing HIV-1 and SIVmac infections in humans and macaques (MACS) is not found in the non-pathogenic SIVagm infection in African green monkeys (AGMs). We have previously shown that TGF-β1, Foxp3 and IL-10 are induced very early after SIVagm infection. In SIVmac-infected MACS, plasma TGF-β1 induction persists during primary infection [1]. We raised the hypothesis that MACs are unable to respond to TGF-β1 and thus cannot resorb virus-driven inflammation. We therefore compared the very early expression dynamics of pro- and anti-inflammatory markers as well as of factors involved in the TGF-β1 signaling pathway in SIV-infected AGMs and MACs. Methods: Levels of transcripts encoding for pro- and anti-inflammatory markers (tnf-α, ifn-γ, il-10, t-bet gata-3) as well as for TGF-β1 signaling mediators (smad3, smad4, smad7) were followed by real time PCR in a prospective study enrolling 6 AGMs and 6 MACs. Results: During primary SIVmac infection, up-regulations of tnf-α, ifn-γ and t-bet responses (days 1-16 p.i.) were stronger whereas il-10 response was delayed (4th week p.i.) compared to SIVagm infection. Up-regulation of smad7 (days 3-8 p.i.), a cellular mediator inhibiting the TGF-β1 signaling cascade, characterized SIV-infected MACs. In AGMs, we found increases of gata-3 but not t-bet, a longer lasting up-regulation of smad4 (days 1-21 p.i), a mediator enhancing TGF-β1 signaling, and no smad7 up-regulations. Conclusion: Our data suggest that the inability to resorb virus-driven inflammation and activation during the pathogenic HIV-1/SIVmac infections is associated with an unresponsiveness to TGF-β1. © 2006 Ploquin et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Ploquin, Mickaël J.Y.
France, Paris
Institut Pasteur, Paris
Desoutter, Jean François
France, Paris
Institut Cochin
Santos, Patricia Ribeiro
France, Paris
Institut Cochin
Pandrea, Ivona Vasile
United States, Covington
Tulane National Primate Research Center
United States, New Orleans
Tulane University Health Sciences Center
Diop, Ousmane Madiagne
Senegal, Dakar
Institut Pasteur de Dakar
Hosmalin, Anne
France, Paris
Institut Cochin
Butor, Cécile
France, Paris
Institut Cochin
France, Paris
Université Paris Cité
Barré-Sinoussi, Françoise C.
France, Paris
Institut Pasteur, Paris
Müller-Trutwin, Michaela C.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 33
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1186/1742-4690-3-37
Research Areas
Infectious Diseases
Study Design
Cohort Study