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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Population differences in immune responses to bacille calmette- guérin vaccination in infancy
Journal of Infectious Diseases, Volume 199, No. 6, Year 2009
Notification
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Description
Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-γ response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-γ after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3-13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-γ response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults. © 2009 by the Infectious Diseases Society of America.
Authors & Co-Authors
Lalor, Maeve K.
Unknown Affiliation
Ben-Smith, Anne W.
Unknown Affiliation
Gorak-Stolinska, Patricia M.A.
Unknown Affiliation
Weir, Rosemary E.
Unknown Affiliation
Floyd, Sian
Unknown Affiliation
Blitz, Rose
Unknown Affiliation
Mvula, Hazzie
Unknown Affiliation
Newport, Melanie J.
Unknown Affiliation
Branson, Keith
Unknown Affiliation
McGrath, Nuala M.
Unknown Affiliation
Crampin, Amelia Catharine
Unknown Affiliation
Fine, Paul E.M.
Unknown Affiliation
Dockrell, Hazel M.
Unknown Affiliation
Statistics
Citations: 13
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1086/597069
ISSN:
00221899
Study Design
Cross Sectional Study