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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Proteomic and functional analyses reveal a unique lifestyle for acinetobacter baumannii biofilms and a key role for histidine metabolism
Journal of Proteome Research, Volume 10, No. 8, Year 2011
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Description
Biofilm formation is one of the main causes for the persistence of Acinetobacter baumannii, a pathogen associated with severe infections and outbreaks in hospitals. Here, we performed comparative proteomic analyses (2D-DIGE and MALDI-TOF/TOF and iTRAQ/SCX-LC-MS/MS) of cells at three different conditions: exponential, late stationary phase, and biofilms. These results were compared with alterations in the proteome resulting from exposure to a biofilm inhibitory compound (salicylate). Using this multiple-approach strategy, proteomic patterns showed a unique lifestyle for A. baumannii biofilms and novel associated proteins. Several cell surface proteins (such as CarO, OmpA, OprD-like, DcaP-like, PstS, LysM, and Omp33), as well as those involved in histidine metabolism (like Urocanase), were found to be implicated in biofilm formation, this being confirmed by gene disruption. Although l-His uptake triggered biofilms efficiently in wild-type A. baumannii, no effect was observed in Urocanase and OmpA mutants, while a slight increase was observed in a CarO deficient strain. We conclude that Urocanase plays a crucial role in histidine metabolism leading to biofilm formation and that OmpA and CarO can act as channels for l-His uptake. Finally, we propose a model in which novel proteins are suggested for the first time as targets for preventing the formation of A. baumannii biofilms. © 2011 American Chemical Society.
Authors & Co-Authors
Soares, Nelson C.
Spain, Corunna
Complejo Hospitalario Universitario Juan Canalejo
Aranda, Jesús
Spain, Corunna
Complejo Hospitalario Universitario Juan Canalejo
Bou, Germán
Spain, Corunna
Complejo Hospitalario Universitario Juan Canalejo
Statistics
Citations: 105
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1021/pr101299j
ISSN:
15353907
Research Areas
Genetics And Genomics