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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Parental psychopathology and the risk of suicidal behavior in their offspring: Results from the World Mental Health surveys
Molecular Psychiatry, Volume 16, No. 12, Year 2011
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Description
Previous research suggests that parental psychopathology predicts suicidal behavior among offspring; however, the more fine-grained associations between specific parental disorders and distinct stages of the pathway to suicide are not well understood. We set out to test the hypothesis that parental disorders associated with negative mood would predict offspring suicide ideation, whereas disorders characterized by impulsive aggression (for example, antisocial personality) and anxiety/agitation (for example, panic disorder) would predict which offspring act on their suicide ideation and make a suicide attempt. Data were collected during face-to-face interviews conducted on nationally representative samples (N55 299; age 18) from 21 countries around the world. We tested the associations between a range of parental disorders and the onset and persistence over time (that is, time since most recent episode controlling for age of onset and time since onset) of subsequent suicidal behavior (suicide ideation, plans and attempts) among offspring. Analyses tested bivariate and multivariate associations between each parental disorder and distinct forms of suicidal behavior. Results revealed that each parental disorder examined increased the risk of suicide ideation among offspring, parental generalized anxiety and depression emerged as the only predictors of the onset and persistence (respectively) of suicide plans among offspring with ideation, whereas parental antisocial personality and anxiety disorders emerged as the only predictors of the onset and persistence of suicide attempts among ideators. A dose-response relation between parental disorders and respondent risk of suicide ideation and attempt was also found. Parental death by suicide was a particularly strong predictor of persistence of suicide attempts among offspring. These associations remained significant after controlling for comorbidity of parental disorders and for the presence of mental disorders among offspring. These findings should inform future explorations of the mechanisms of intergenerational transmission of suicidal behavior. © 2011 Macmillan Publishers Limited All rights reserved.
Authors & Co-Authors
Gureje, Oye
Nigeria, Ibadan
University College Hospital, Ibadan
Oladeji, Bibilola Damilola
Nigeria, Ibadan
University College Hospital, Ibadan
Hwang, Irving H.
United States, Boston
Harvard Medical School
Chiu, Wai Tat
United States, Boston
Harvard Medical School
Kessler, Ronald C.
United States, Boston
Harvard Medical School
Sampson, Nancy A.
United States, Boston
Harvard Medical School
Alonso Caballero, J. L.
Spain, Barcelona
Hospital Del Mar
Andrade, Laura Helena Silveira Guerra
Brazil, Sao Paulo
Universidade de São Paulo
Beautrais, Annette
New Zealand, Christchurch
University of Otago, Christchurch
Borges, Guilherme Luiz Guimaraes
Mexico, Mexico
Instituto Nacional de Psiquiatría Ramon de la Fuente
Bromet, Evelyn J.
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Bruffaerts, Ronny
Belgium, Leuven
Ku Leuven
de Girolamo, Giovanni
Italy, Bologna
Irccs Rizzoli Orthopaedic Institute, Bologna
de Graaf, Ron
Netherlands, Utrecht
Trimbos Institute, Netherlands Institute of Mental Health and Addiction
Gal, Gilad
Israel, Tel Hashomer
The Gertner Institute
He, Yanling
China, Shanghai
Shanghai Mental Health Center
Hu, Chiyi
China, Guangdong
Shenzhen Institute of Mental Health
Iwata, Noboru
Japan, Hiroshima
Hiroshima International University
Karam, Elie Georges
Lebanon, Beirut
Saint George Hospital University Medical Center
Kovess - Masfety, Viviane
France, Paris
Université Paris Cité
Matschinger, Herbert
Germany, Leipzig
Universität Leipzig
Moldovan, M. V.
Romania, Bucharest
National School of Public Health
Posada-Villa, J. A.
Colombia, Bogota
Saldarriaga Concha Foundation
Sagar, Rajesh Pragna
India, New Delhi
All India Institute of Medical Sciences, new Delhi
Scocco, P.
Unknown Affiliation
Seedat, Soraya
South Africa, Tygerberg
South African Medical Research Council
Tomov, Toma
Bulgaria, Sofia
New Bulgarian University
Nock, Matthew K.
United States, Cambridge
Harvard University
Statistics
Citations: 76
Authors: 28
Affiliations: 23
Identifiers
Doi:
10.1038/mp.2010.111
ISSN:
13594184
e-ISSN:
14765578
Research Areas
Mental Health
Study Design
Cross Sectional Study