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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
N-3 fatty acids and cardiovascular outcomes in patients with dysglycemia
New England Journal of Medicine, Volume 367, No. 4, Year 2012
Notification
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Description
Background: The use of n-3 fatty acids may prevent cardiovascular events in patients with recent myocardial infarction or heart failure. Their effects in patients with (or at risk for) type 2 diabetes mellitus are unknown. Methods: In this double-blind study with a 2-by-2 factorial design, we randomly assigned 12,536 patients who were at high risk for cardiovascular events and had impaired fasting glucose, impaired glucose tolerance, or diabetes to receive a 1-g capsule containing at least 900 mg (90% or more) of ethyl esters of n-3 fatty acids or placebo daily and to receive either insulin glargine or standard care. The primary outcome was death from cardiovascular causes. The results of the comparison between n-3 fatty acids and placebo are reported here. Results: During a median follow up of 6.2 years, the incidence of the primary outcome was not significantly decreased among patients receiving n-3 fatty acids, as compared with those receiving placebo (574 patients [9.1%] vs. 581 patients [9.3%]; hazard ratio, 0.98; 95% confidence interval [CI], 0.87 to 1.10; P = 0.72). The use of n-3 fatty acids also had no significant effect on the rates of major vascular events (1034 patients [16.5%] vs. 1017 patients [16.3%]; hazard ratio, 1.01; 95% CI, 0.93 to 1.10; P = 0.81), death from any cause (951 [15.1%] vs. 964 [15.4%]; hazard ratio, 0.98; 95% CI, 0.89 to 1.07; P = 0.63), or death from arrhythmia (288 [4.6%] vs. 259 [4.1%]; hazard ratio, 1.10; 95% CI, 0.93 to 1.30; P = 0.26). Triglyceride levels were reduced by 14.5 mg per deciliter (0.16 mmol per liter) more among patients receiving n-3 fatty acids than among those receiving placebo (P<0.001), without a significant effect on other lipids. Adverse effects were similar in the two groups. Conclusions: Daily supplementation with 1 g of n-3 fatty acids did not reduce the rate of cardiovascular events in patients at high risk for cardiovascular events. (Funded by Sanofi; ORIGIN ClinicalTrials.gov number, NCT00069784.). Copyright © 2012 Massachusetts Medical Society.
Authors & Co-Authors
Bosch, Jackie J.
Canada, Hamilton
Population Health Research Institute, Ontario
Gerstein, Hertzel C.
Canada, Hamilton
Hamilton Health Sciences
Dagenais, Gilles R.
Canada, Quebec
Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval
Díaz, Rafaël J.
Argentina, Rosario
Estudios Clínicos Latinoamérica
Dyal, Leanne
Canada, Hamilton
Population Health Research Institute, Ontario
Jung, Hyejung
Canada, Hamilton
Population Health Research Institute, Ontario
Probstfield, Jeffrey L.
United States, Seattle
University of Washington
Ramachandran, Ambady
India, Chennai
India Diabetes Research Foundation
Riddle, Matthew C.
United States, Portland
Oregon Health & Science University
Ryde´n, Lårs E.
Sweden, Stockholm
Karolinska Institutet
Yusuf, Salim N.
Canada, Hamilton
Hamilton Health Sciences
Johnston, Peter S.
Unknown Affiliation
Birkeland, Kàre Inge
Unknown Affiliation
Budaj, Andrzej J.
Unknown Affiliation
Commerford, Patrick Joseph
Unknown Affiliation
Davies, Melanie J.
Unknown Affiliation
Fodor, Jiri George
Unknown Affiliation
Gilbert, Richard E.
Unknown Affiliation
Gomis, Ramón
Unknown Affiliation
Hanefeld, Markolf G.
Unknown Affiliation
Hildebrandt, Per Rossen
Unknown Affiliation
Keltai, Mátyás
Unknown Affiliation
Krum, Henry
Unknown Affiliation
Lewis, Basil S.
Unknown Affiliation
Lönn, Eva Marie
Unknown Affiliation
López-Jaramillo, P.
Unknown Affiliation
Marin-Neto, José Antonio
Unknown Affiliation
Marre, Michel
Unknown Affiliation
McKelvie, Robert Samuel
Unknown Affiliation
McQueen, Matthew J.
Unknown Affiliation
Mendoza, Iván Bahena
Unknown Affiliation
Morillo, Carlos A.
Unknown Affiliation
Pan, Changyu
Unknown Affiliation
Pirags, Valdis
Unknown Affiliation
Profozić, Velimir
Unknown Affiliation
Ratner, Robert E.
Unknown Affiliation
Rosenstock, Julio
Unknown Affiliation
Sreenan, Seamus K.
Unknown Affiliation
Avezum, Álvaro Jr
Unknown Affiliation
Bahit, María Cecilia
Unknown Affiliation
Bogaty, Peter M.
Unknown Affiliation
Halon, David A.
Unknown Affiliation
Magloire, Patrick
Unknown Affiliation
Mann, Johannes F.E.
Unknown Affiliation
Punthakee, Zubin
Unknown Affiliation
Ahmad, Soban
Unknown Affiliation
Chandra, Ronil V.
Unknown Affiliation
Cukierman-Yaffe, Tali
Unknown Affiliation
Joldersma, L.
Unknown Affiliation
Tyrwhitt, Jessica
Unknown Affiliation
Ahuad-Guerrero, Rodolfo Andres
Unknown Affiliation
Alebuena, Andrea
Unknown Affiliation
Baglivo, Hugo P.
Unknown Affiliation
Barbieri, Maria
Unknown Affiliation
Bono, Julio Oscar Emilio
Unknown Affiliation
Bustamante-Labarta, Miguel H.
Unknown Affiliation
Bustos, Betina
Unknown Affiliation
Caccavo, Alberto
Unknown Affiliation
Camino, Alejandra Mabel
Unknown Affiliation
Cantero, Maria Cecilia
Unknown Affiliation
Cartasegna, Luis Rodolfo
Unknown Affiliation
Cipullo, Marcela A.
Unknown Affiliation
Crespo, Claudia J.
Unknown Affiliation
Cuello, Jose L.
Unknown Affiliation
Cuneo, Carlos Alberto
Unknown Affiliation
Dituro, Claudio Fabián
Unknown Affiliation
Domínguez, Antonio Reyes
Unknown Affiliation
Farah, Miguel
Unknown Affiliation
Fernández, Alberto Alfredo
Unknown Affiliation
Garrido, Marcelo A.
Unknown Affiliation
Hasbani, Eduardo G.
Unknown Affiliation
Hominal, Miguel Angel
Unknown Affiliation
Hrabar, Adrián D.
Unknown Affiliation
Lanchiotti, Paulina Virginia
Unknown Affiliation
Lobo Márquez, Lilia Luz Del Valle
Unknown Affiliation
López Santi, Ricardo G.
Unknown Affiliation
Majul, Claudio Rodolfo
Unknown Affiliation
Marino, Marcello
Unknown Affiliation
Montaña, Oscar R.
Unknown Affiliation
Orlandini, Andrés D.
Unknown Affiliation
Pelagagge, María Jose
Unknown Affiliation
Plastino, Maria Laura
Unknown Affiliation
Prado, Aldo
Unknown Affiliation
Ramírez, Alfredo Echevarria
Unknown Affiliation
Rodríguez, Monica J.
Unknown Affiliation
Ronderos, Ricardo Ernesto
Unknown Affiliation
Schygiel, Pablo Omar
Unknown Affiliation
Sinay, Isaac Rubén
Unknown Affiliation
Vico, Marisa Liliana
Unknown Affiliation
Villamil, Alberto S.
Unknown Affiliation
Vogel, Daniel R.
Unknown Affiliation
Zaidman, Cesar Javier
Unknown Affiliation
Amerena, John V.
Unknown Affiliation
Aylward, Philip E.G.
Unknown Affiliation
Colman, P. G.
Unknown Affiliation
Colquhoun, David M.
Unknown Affiliation
Gordon, Gary D.
Unknown Affiliation
Sullivan, David R.
Unknown Affiliation
Teede, Helena J.
Unknown Affiliation
Torpy, David James
Unknown Affiliation
Williams, Lyn Keoki
Unknown Affiliation
Yeap, Bu Beng
Unknown Affiliation
Drexel, Heinz
Unknown Affiliation
Präger, Rudolf J.F.
Unknown Affiliation
Thomas, Baby M.
Unknown Affiliation
Toplak, Hermann
Unknown Affiliation
Lazareva, Irina
Unknown Affiliation
Sudzhaeva, Svetlana G.
Unknown Affiliation
Alves, Marco G.
Unknown Affiliation
Barros, Marianela
Unknown Affiliation
Costa, Francisco Manuel Moscoso
Unknown Affiliation
Figueiredo, Jane C.
Unknown Affiliation
Costa-E-Forti, Adriana E.
Unknown Affiliation
Franco, Denise Reis
Unknown Affiliation
Franken, Marcelo
Unknown Affiliation
Manenti, Euler Roberto Fernandes
Unknown Affiliation
Seixas, Azizi A.
Unknown Affiliation
Abbott, Carlo
Unknown Affiliation
Baillargeon, Jean-Patrice Patrice
Unknown Affiliation
Carpentier, André C. C.
Unknown Affiliation
Chan, Yih Kai
Unknown Affiliation
Chiasson, Jean Louis
Unknown Affiliation
Gosselin, Gilbert
Unknown Affiliation
Harper, William L.
Unknown Affiliation
Hivert, Marie France
Unknown Affiliation
Ho, Kim L.
Unknown Affiliation
Joyce, Carol
Unknown Affiliation
Lavoie, Marc André
Unknown Affiliation
Ma, Patrick T.S.
Unknown Affiliation
Nyomba, B. L.Grégoire
Unknown Affiliation
Shaban, Joseph A.
Unknown Affiliation
Thèroux, Pierre A.
Unknown Affiliation
Warnica, James Wayne
Unknown Affiliation
Woo, Vincent C.
Unknown Affiliation
Yale, Jean François
Unknown Affiliation
Bi, Yufang
Unknown Affiliation
Chen, Bin
Unknown Affiliation
Han, Xiaoning
Unknown Affiliation
Ji, Linong
Unknown Affiliation
Jia, Weiping
Unknown Affiliation
Li, Qifu
Unknown Affiliation
Peng, Yongde
Unknown Affiliation
Tian, Huiguang
Unknown Affiliation
Accini, José Luis
Unknown Affiliation
Cure, Carlos
Unknown Affiliation
Pérez, Maritza Lemani
Unknown Affiliation
Urina-Triana, Miguel
Unknown Affiliation
Christensen, Per Dahl
Unknown Affiliation
Hermansen, Kjeld
Unknown Affiliation
Jeppesen, Jørgen Lykke
Unknown Affiliation
Klausen, Ib Christian
Unknown Affiliation
Krarup, Thure
Unknown Affiliation
Torp-Pedersen, Christian Tobias
Unknown Affiliation
Eriksson, Jan W.
Unknown Affiliation
Niskanen, Leo K.
Unknown Affiliation
Saltevo, Juha T.
Unknown Affiliation
Böhme, P.
Unknown Affiliation
Charpentier, Guillaume
Unknown Affiliation
Duengler, Frédérique
Unknown Affiliation
Guerci, Bruno
Unknown Affiliation
Hadjadj, Samy
Unknown Affiliation
Maréchaud, Richard
Unknown Affiliation
Pinel, Jean François
Unknown Affiliation
Raccah, Denis
Unknown Affiliation
Reznik, Yves
Unknown Affiliation
Torremocha, Florence
Unknown Affiliation
Travert, Florence
Unknown Affiliation
Adamidou, Aikatarini
Unknown Affiliation
Forst, Thomas
Unknown Affiliation
Hamann, Andreas
Unknown Affiliation
Humpert, Per Magnus
Unknown Affiliation
Morcos, Michael
Unknown Affiliation
Nguyen, Michel
Unknown Affiliation
Pauly, Bruno
Unknown Affiliation
Pfeiffer, Andreas F.H.
Unknown Affiliation
Reismann, Peter
Unknown Affiliation
Schaper, Frank
Unknown Affiliation
Schumm-Draeger, Petra Maria
Unknown Affiliation
Kempler, Péter
Unknown Affiliation
Sereg, Mátyás
Unknown Affiliation
Szabo, Aniko
Unknown Affiliation
Chamukuttan, Snehalatha
Unknown Affiliation
Lal, Priti
Unknown Affiliation
Mithal, Ambrish
Unknown Affiliation
Mohan, Viswanathan Krishna
Unknown Affiliation
Pais, Prem S.
Unknown Affiliation
Pendsey, Sharad P.
Unknown Affiliation
Rao, Paturi Vishnupriya
Unknown Affiliation
Thomas, Nihal Jacob
Unknown Affiliation
Cullen, Marc L.
Unknown Affiliation
Khan, Maheer U.
Unknown Affiliation
O'Halloran, Domhnaill J.
Unknown Affiliation
Cohen, Ohad
Unknown Affiliation
Halabi, Susan
Unknown Affiliation
Harman-Boehm, Ilana
Unknown Affiliation
Raz, Itamar
Unknown Affiliation
Zahger, Doron
Unknown Affiliation
Zeltser, David W.
Unknown Affiliation
Zimlíchman, Reuven R.
Unknown Affiliation
Cacciatore, Francesco
Unknown Affiliation
del Prato, Stefano
Unknown Affiliation
Fanelli, Raffaele
Unknown Affiliation
Sesti, Giorgio
Unknown Affiliation
Jeong, Myungho
Unknown Affiliation
Oh, Seungjoon
Unknown Affiliation
Seung, Ki-bae
Unknown Affiliation
Rasa, Ingvars
Unknown Affiliation
Badarienė, Jolita
Unknown Affiliation
Petrulioniene, Žaneta
Unknown Affiliation
Šakalyte, Gintare
Unknown Affiliation
Urbonaité, Bronislava K.
Unknown Affiliation
Arechavaleta, Rosario
Unknown Affiliation
Illescas, J.
Unknown Affiliation
Badings, Erik A.
Unknown Affiliation
Cornel, Jan Hein
Unknown Affiliation
de Swart, Johannes Bernadus Robertus Maria
Unknown Affiliation
Holwerda, Nicolaas J.H.
Unknown Affiliation
Liem, Anho
Unknown Affiliation
Nierop, Pieter R.
Unknown Affiliation
Ronner, Eelko F.
Unknown Affiliation
van Hessen, Maarten W.J.
Unknown Affiliation
Willems, Frank F.
Unknown Affiliation
Joakimsen, Ragnar Martin
Unknown Affiliation
Jorde, Rolf
Unknown Affiliation
Panelo, Araceli A.
Unknown Affiliation
Ramos, Grazielle Viana
Unknown Affiliation
Statistics
Citations: 743
Authors: 226
Affiliations: 9
Identifiers
Doi:
10.1056/NEJMoa1203859
ISSN:
00284793
Research Areas
Disability
Environmental
Noncommunicable Diseases
Study Design
Cohort Study