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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Piloting the effective therapeutic dose of adjunctive selective estrogen receptor modulator treatment in postmenopausal women with schizophrenia
Psychoneuroendocrinology, Volume 35, No. 8, Year 2010
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Description
Estrogen treatment may enhance the recovery of schizophrenia in women. However, adverse effects on uterine and breast tissue and other physical side effects may limit the long-term therapeutic use of estrogen. Raloxifene hydrochloride is a selective estrogen receptor modulator that acts as an estrogen antagonist in breast tissue and may have agonistic actions in the brain, potentially offering mental health benefits with few estrogenic side effects. To provide an indication of the potential therapeutic dose for raloxifene hydrochloride in postmenopausal women with schizophrenia, this study pools data from an ongoing randomized controlled trial of adjunctive 120. mg/day oral raloxifene hydrochloride (n= 13) versus oral placebo (n= 13), with data from a previous pilot study administering 60. mg/day raloxifene hydrochloride (n= 9). Analysis of variance found significant interaction effects for total (p=01) and general (p=02) Positive and Negative Syndrome Scale (PANSS) symptomatology. Participants randomized to receive 120. mg/day raloxifene hydrochloride experienced a significantly more rapid recovery of total and general psychotic symptoms compared to both 60. mg/day raloxifene hydrochloride and placebo. The demonstrated benefit of adjunctive treatment with 120mg/day raloxifene hydrochloride offers support for the potential role of this selective estrogen receptor modulator in treating postmenopausal women with schizophrenia. © 2010 Elsevier Ltd.
Authors & Co-Authors
Kulkarni, Jayashri
Australia, Clayton
Monash University
Berk, Michael
Australia, Geelong
Barwon Health
Australia, Melbourne
Orygen Research Centre
Australia, Melbourne
The Florey
Dodd, Seetal M.
Australia, Geelong
Barwon Health
Davis, Susan R.
Australia, Clayton
Monash University
Statistics
Citations: 109
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.psyneuen.2010.01.014
ISSN:
03064530
Research Areas
Health System And Policy
Mental Health
Study Approach
Quantitative
Participants Gender
Female