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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Voriconazole as a first-line treatment against potentially pathogenic Acanthamoeba strains from Peru
Parasitology Research, Volume 113, No. 2, Year 2014
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Description
Pathogenic strains of Acanthamoeba genus are the causative agents of fatal granulomatous amoebic encephalitis and a serious sight-threatening infection of the eye known as Acanthamoeba keratitis. In a previous study, Acanthamoeba strains were isolated from nasal swabs collected from healthy individuals in Peru. In the present study, the pathogenic potential of the isolated strains was established based on temperature and osmotolerance assays as well as the secretion rate of extracellular proteases. Based on these experiments, four strains that showed the highest pathogenic potential were selected for sensitivity assays against two molecules (voriconazole and chlorhexidine) which are currently used for the treatment of Acanthamoeba infections. After performing sensitivity and activity assays, it was found that both drugs were active against the tested strains. However, voriconazole showed higher activity against the studied strains compared to chlorhexidine. Therefore, voriconazole should be established as a first-line treatment against Acanthamoeba infections at least in the studied region of Peru. © 2013 Springer-Verlag Berlin Heidelberg.
Authors & Co-Authors
Cabello-Vílchez, Alfonso Martín
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
Martín-Navarro, Carmen Ma
Spain, San Cristobal de la Laguna
Universidad de la Laguna
United Kingdom, Edinburgh
The University of Edinburgh
López-Arencibia, Atteneri
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Reyes-Batlle, María
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Sifaoui, Ines
Tunisia, La Marsa
University of Carthage, Ecole Polytechnique de Tunisie
Valladares, Basilio
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Piñero Barroso, J. E.
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Lorenzo-Morales, Jacob
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Statistics
Citations: 39
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1007/s00436-013-3705-8
ISSN:
09320113
e-ISSN:
14321955
Research Areas
Health System And Policy