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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Role of angiotensin II and angiotensin-(1-7) in diabetes-induced oxidative DNA damage in the corpus cavernosum
Fertility and Sterility, Volume 100, No. 1, Year 2013
Notification
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Description
Objective: To investigate diabetes mellitus (DM)-induced oxidative DNA damage, putative involvement of angiotensin (Ang) II, and possible modulatory effects of Ang-(1-7) in rat corpus cavernosum (CC). Design: In vivo study. Setting: Research laboratory. Animal(s): Adult male Wistar rats. Intervention(s): Streptozotocin-induced diabetic rats received either captopril, losartan (both 300 mg/L in drinking water), or Ang-(1-7) (576 μg/kg/d IP) for a 3-week period immediately before sacrifice at 6 weeks of DM. Main Outcome Measure(s): Histopathological changes in CC were examined in Masson's trichrome-stained tissue sections. Oxidative stress was evaluated by measuring total oxidant status and antioxidant status. The DNA damage was estimated by measuring 8-hydroxy-2′-deoxyguanosine by immunohistochemistry and ELISA. Result(s): The CC smooth muscle degeneration was observed in association with an increase in total oxidant status and a decrease in total antioxidant status in rats with DM. Oxidative DNA damage was significantly increased in both cytoplasm and nuclei of CC in DM. Treatment with captopril, losartan, or Ang-(1-7) inhibited these changes in rats with DM. Conclusion(s): The data indicate that Ang II signaling is involved in DM-induced structural changes and oxidative DNA damage in the CC and that modulation of the signaling by captopril, losartan, and Ang-(1-7) restores the effects of DM. Thus, Ang-(1-7)/MAS1 axis may be a novel therapeutic target for erectile dysfunction in DM. Copyright © 2013 Published by Elsevier Inc.
Authors & Co-Authors
Kilarkaje, Narayana
Kuwait, Kuwait City
Kuwait University
Yousif, Mariam H.M.
Kuwait, Kuwait City
Kuwait University
El-Hashim, Ahmed Z.
Kuwait, Kuwait City
Kuwait University
Makki, Batoul
Kuwait, Kuwait City
Kuwait University
Akhtar, Saghir
Kuwait, Kuwait City
Kuwait University
Benter, Ibrahim Fadil
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 33
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1016/j.fertnstert.2013.02.046
ISSN:
00150282
e-ISSN:
15565653
Research Areas
Environmental
Genetics And Genomics
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Participants Gender
Male