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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A DS-1 like G9P[6] human strain CDC-6 as a new rotavirus vaccine candidate
Vaccine, Volume 36, No. 45, Year 2018
Notification
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Description
Human rotavirus vaccine Rotarix® (G1P[8]) has shown broad cross protection against homotypic and heterotypic Wa-like human rotavirus strains among children worldwide. This vaccine, however, appears to induce slightly less or non-consistent protection against DS-1 like rotavirus P[4] strains in some settings. In addition, children who are secretor or Lewis-negative and are vaccinated with Rotarix® often experience breakthrough infection with P[6] strains. By contrast, P[6] strains infect all children, irrespective of their secretor or Lewis status. In the present study, we report successful adaptation of a DS-1 like human rotavirus G9P[6] strain (CDC-6) to high growth in Vero cells and identify sequence changes that may be critical for enhanced growth in vitro and attenuation in vivo. This human G9P[6] strain could serve as a promising new and potential low-cost vaccine candidate for global use, particularly in targeted population with secretor or Lewis-negative status and high prevalent DS-1 like P[6] strains. © 2018
Authors & Co-Authors
Wang, Yuhuan
United States, Atlanta
Centers for Disease Control and Prevention
Esona, Mathew Dioh
United States, Atlanta
Centers for Disease Control and Prevention
Moon, Sungsil
United States, Atlanta
Centers for Disease Control and Prevention
Jiang, Baoming
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 1
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.vaccine.2018.08.055
ISSN:
0264410X
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study