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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Anti-HPA-1b mediated posttransfusion purpura: A case report
Case Reports in Medicine, Volume 2013, Article 568364, Year 2013
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Description
Posttransfusion purpura (PTP) is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion. Although there is evidence of a wide serological spectrum of culprit antibodies implicated, Anti-human-platelet-antigen- (HPA-) 1a is the most common antibody in cases reported. We report a case of posttransfusion purpura in an African American. The patient was negative for HPA-1a antibodies, but anti-HPA-1b was identified with a platelet phenotype of HPA-1a/HPA-1a. Although less common, HPA-1b antibody may be an important consideration in posttransfusion purpura diagnosed in patients of African descent. © 2013 O. P. Arewa et al.
Authors & Co-Authors
Arewa, Oladimeji P.
Saudi Arabia, Arar
Arar Central Hospital
Nahirniak, Susan M.
Canada, Edmonton
University of Alberta Hospital
Clarke, G.
Canada, Edmonton
University of Alberta Hospital
Statistics
Citations: 7
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1155/2013/568364
ISSN:
16879627
e-ISSN:
16879635
Research Areas
Health System And Policy