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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: Pharmacogenetic effect of CYP2B6 variation
Journal of Clinical Pharmacology, Volume 48, No. 9, Year 2008
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Description
The goal of this study was to determine the effect of CYP2B6 genetic variation on the steady-state pharmacokinetics of efavirenz (600 mg/d) in TB/HIV co-infected patients receiving concomitant rifampin, a potent CYP inducer. In the 26 patients studied, CYP2B6 c.516GG, GT, and TT genotype frequencies were 0.27, 0.50, and 0.23, respectively. Mean plasma efavirenz area under the curve was significantly higher in patients with CYP2B6 c.516TT than in those with GT (107 vs 27.6 μg·h/mL, P <.0001) or GG genotype (107 vs 23.0 μg· h/mL, P <.0001). Apparent oral clearance (CL/F) was significantly lower in patients with CYP2B6 c.516TT than in those with GT genotype (2.1 vs 8.4 mL/min/kg, P < 0.0001) and GG genotype (2.1 vs 9.9 mL/min/kg, P <.0001). No differences in efavirenz exposure or CL/F existed between patients with CYP2B6 c.516GT and GG genotypes. Our results indicate that CYP2B6 c.516TT genotype can be used to identify efavirenz poor metabolizers in patients co-treated with rifampin. © 2008 the American College of Clinical Pharmacology.
Authors & Co-Authors
Kwara, Awewura
United States, Providence
Miriam Hospital
United States, Providence
The Warren Alpert Medical School
Lartey, Margaret Yaa
Ghana, Accra
University of Ghana
Sagoe, Kwamena William Coleman
Ghana, Accra
University of Ghana
Xexemeku, Fafa
Ghana, Accra
Korle bu Teaching Hospital
Kenu, Ernest
Ghana, Accra
Korle bu Teaching Hospital
Oliver-Commey, Joseph O.
Ghana, Accra
Korle bu Teaching Hospital
Boima, Vincent
Ghana, Accra
Korle bu Teaching Hospital
Sagoe, Augustine
Ghana, Accra
Korle bu Teaching Hospital
Boamah, Isaac
Ghana, Accra
University of Ghana
Greenblatt, David J.
United States, Boston
Tufts University School of Medicine
Court, Michael H.
United States, Boston
Tufts University School of Medicine
Statistics
Citations: 50
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1177/0091270008321790
e-ISSN:
15524604
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases