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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil
Science Advances, Volume 9, No. 35, Article eadg9204, Year 2023
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Description
Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated Aedes aegypti was able to capture the seasonality of reported human infections. Spatial modeling revealed spatial hotspots with both past reporting and low vaccination coverage, which coincided with many of the largest urban centers in the Southeast. Phylodynamic analysis unraveled the circulation of three distinct lineages and provided proof of the directionality of a known spatial corridor that connects the endemic North with the extra-Amazonian basin. This study illustrates that genomics linked with eco-epidemiology can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control. Copyright © 2023 The Authors.
Authors & Co-Authors
Giovanetti, Marta
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Italy, Rome
Università Campus Bio-medico Di Roma
Pinotti, Francesco
United Kingdom, Oxford
University of Oxford
Zanluca, Camila
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Fonseca, Vagner S.
Brazil, Brasilia
Organização Pan-americana da Saúde/organização Mundial da Saúde
Adelino, Talita Émile Ribeiro
Brazil, Belo Horizonte
Fundacao Ezequiel Dias
Xavier, Joilson R.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
de Oliveira, Carla
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Guimarães, Natalia Rocha
Brazil, Belo Horizonte
Fundacao Ezequiel Dias
Fritsch, Hegger Machado
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Mares-Guia, Maria Angélica Monteiro De Mello
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Levy, Flávia
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
da Silva, Vinícius Lemes
Brazil, Goiania
Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros
Pereira, Luiz Augusto
Brazil, Goiania
Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros
Mendonça, Ana Flávia
Brazil, Goiania
Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros
Abreu, Filipe Vieira Santos De
Brazil, Salinas
Federal Institute of Northern Minas Gerais
Campos, Fabrício Souza
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
de Melo Iani, Felipe Campos
Brazil, Belo Horizonte
Fundacao Ezequiel Dias
Pereira, Maira Alves
Brazil, Belo Horizonte
Fundacao Ezequiel Dias
Cavalcante, Karina Ribeiro Leite Jardim
Unknown Affiliation
de Albuquerque, Carlos Frederico Campelo
Brazil, Brasilia
Organização Pan-americana da Saúde/organização Mundial da Saúde
Macário, Eduardo Marques
Unknown Affiliation
Campos, Aline Alves Scarpellini
Brazil, Porto Alegre
Centro Estadual de Vigilância em Saúde
Riediger, Irina Nastassja
Brazil, Curitiba
Laboratório Central de Saúde Pública do Estado do Paraná Lacen-pr
Ribeiro, Sérvio Pontes
Brazil, Ouro Preto
Universidade Federal de Ouro Preto
De Oliveira, Tulio
South Africa, Stellenbosch
Stellenbosch University
Freitas, Carla L.
Brazil, Brasilia
Ministério da Saúde
de Moura, Noely Fabiana Oliveira
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Fabri, Allison Araújo
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Dos Santos Rodrigues, Cintia Damasceno
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Dos Santos, Carolina Cardoso
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
de Almeida, Marco Antônio Barreto
Brazil, Porto Alegre
Centro Estadual de Vigilância em Saúde
Dos Santos, Edmilson
Brazil, Porto Alegre
Centro Estadual de Vigilância em Saúde
Cardoso, Jáder Da Cruz
Brazil, Porto Alegre
Centro Estadual de Vigilância em Saúde
Stábeli, Rodrigo Guerino
Brazil, Brasilia
Organização Pan-americana da Saúde/organização Mundial da Saúde
Navegantes, Wildo Araujo
Brazil, Brasilia
Organização Pan-americana da Saúde/organização Mundial da Saúde
Ferreira, Álvaro Gil Araújo
Unknown Affiliation
de Almeida Medeiros, Daniele Barbosa A.
Brazil, Ananindeua
Instituto Evandro Chagas
Cruz, Ana Cecília Ribeiro
Brazil, Ananindeua
Instituto Evandro Chagas
Cunha, R.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
van Voorhis, Wesley C.
United States, Seattle
University of Washington
de Filippis, Ana Maria Bispo
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Almirón, María
United States, Washington, D.c.
Pan American Health Organization
Holmes, Edward C.
Australia, Sydney
The University of Sydney
Ramos, Daniel G.
Unknown Affiliation
Romano, Alessandro Pecego Martins
Unknown Affiliation
Lourenço, José M.L.
Portugal, Lisbon
Universidade de Lisboa
Junior Alcantara, Luiz Carlos
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Statistics
Citations: 1
Authors: 47
Affiliations: 26
Identifiers
Doi:
10.1126/sciadv.adg9204
ISSN:
23752548
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases