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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
A feasibility study of quantifying longitudinal brain changes in herpes simplex virus (HSV) encephalitis using magnetic resonance imaging (MRI) and stereology
PLoS ONE, Volume 12, No. 1, Article e0170215, Year 2017
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Description
Objectives To assess whether it is feasible to quantify acute change in temporal lobe volume and total oedema volumes in herpes simplex virus (HSV) encephalitis as a preliminary to a trial of corticosteroid therapy. Methods The study analysed serially acquired magnetic resonance images (MRI), of patients with acute HSV encephalitis who had neuroimaging repeated within four weeks of the first scan. We performed volumetric measurements of the left and right temporal lobes and of cerebral oedema visible on T2 weighted Fluid Attenuated Inversion Recovery (FLAIR) images using stereology in conjunction with point counting. Results Temporal lobe volumes increased on average by 1.6% (standard deviation (SD 11%) in five patients who had not received corticosteroid therapy and decreased in two patients who had received corticosteroids by 8.5%. FLAIR hyperintensity volumes increased by 9% in patients not receiving treatment with corticosteroids and decreased by 29% in the two patients that had received corticosteroids. Conclusions This study has shown it is feasible to quantify acute change in temporal lobe and total oedema volumes in HSV encephalitis and suggests a potential resolution of swelling in response to corticosteroid therapy. These techniques could be used as part of a randomized control trial to investigate the efficacy of corticosteroids for treating HSV encephalitis in conjunction with assessing clinical outcomes and could be of potential value in helping to predict the clinical outcomes of patients with HSV encephalitis. © 2017 Defres et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Authors & Co-Authors
Defres, Sylviane
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
Keller, Simon Sean
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Das, Kumar V.
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Burnside, Girvan
United Kingdom, Liverpool
University of Liverpool
Griffiths, Michael John
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Kopelman, Michael D.
United Kingdom, London
King's College London
Solomon, Tom
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Baker, Gus A.
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Beeching, Nicholas J.
United Kingdom, Liverpool
Royal Liverpool University Hospital
Brown, David W.G.
United Kingdom, London
Public Health England
Carrol, Enitan D.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Hospital
Davies, Nicholas W.S.
United Kingdom, London
Chelsea and Westminster Hospital Nhs Foundation Trust
Easton, Ava
Unknown Affiliation
Eccles, Martin Paul
United Kingdom, Newcastle
Newcastle University
García-Fiñana, Marta
United Kingdom, Liverpool
University of Liverpool
Jacoby, Ann
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Hardwick, Hayley E.
United Kingdom, Liverpool
University of Liverpool
Cooper, Jessie
United Kingdom, Liverpool
University of Liverpool
Kneen, Rachel
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Hospital
Levin, Michael E.
United Kingdom, London
Imperial College London
Medina-Lara, Antonieta
United Kingdom, Exeter
University of Exeter Medical School
Michael, Benedict Daniel
United Kingdom, Liverpool
University of Liverpool
Sadarangani, Manish
United Kingdom, Oxford
University of Oxford
Pollard, Andrew J.
United Kingdom, Oxford
University of Oxford
Vincent, Angela V.
United Kingdom, Oxford
University of Oxford
Warlow, Charles P.
United Kingdom, Edinburgh
Western General Hospital
Statistics
Citations: 5
Authors: 26
Affiliations: 21
Identifiers
Doi:
10.1371/journal.pone.0170215
ISSN:
19326203
Research Areas
Health System And Policy
Study Design
Cohort Study