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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
North African and Southeast Asian nasopharyngeal carcinomas: Between the resemblance and the dissemblance
Bulletin du Cancer, Volume 97, No. 4, Year 2010
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Description
Nasopharyngeal carcinoma (NPC) is an unusual head and neck cancer because of its unequal geographical distribution and its consistent association with the Epstein-Barr virus (EBV). This malignant tumor poses a serious public health problem in many countries, especially in Southeast Asia and North Africa where the recorded incidence are highest. During the past decade, a growing number of studies were undertaken to define the molecular basis of NPC. However, the analysis of several clinical and biological parameters of North African and Southeast Asian NPCs has shown notable differences, suggesting that they could result from a distinct combination of etiological factors. One intriguing characteristic of North African NPC, concerns its bimodal age distribution with a secondary peak of incidence in the range of 15-25 years, not observed in Asian NPC. In this juvenile formof NPC, immunohistochemistry assay has shown that the two key proteins controlling the apoptotic-survival balance p53 and Bcl-2 are less frequently expressed whereas the transmembrane tyrosine-kinase receptor c-kit and the main EBV oncoprotein LMP1 were more abundant. In addition, the EBV serological alterations are less informative for the diagnosis of the juvenile compared to the adult form. In addition, most North African NPCs contain EBV strains with genetic polymorphisms distinct from those described in the Southeast Asia series (predominance of F, D, H1-H2, XhoI+ and f, C, H, XhoI- respectively). In contrast, studies relating on tumor chromosomal alterations or aberrant promoter methylation result in data very similar to those obtained from the Southeast Asia series, supporting the concept of a common molecular basis for all NPC regardless of patient geographic origin.▲ ©John Libbey Eurotext.
Authors & Co-Authors
Ayadi, Wajdi
Tunisia, Sfax
Chu Habib Bourguiba
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Khabir, Abdelmajid
Tunisia, Sfax
Chu Habib Bourguiba
Hadhri-Guiga, Boutheina
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Fki, Lamia
Tunisia, Sfax
Chu Habib Bourguiba
Toumi, Nabil
Tunisia, Sfax
Chu Habib Bourguiba
Siala, Wissem
Tunisia, Sfax
Chu Habib Bourguiba
Charfi, Slim
Tunisia, Sfax
Chu Habib Bourguiba
Fendri, Ali
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Makni, Hafedh
Tunisia, Sfax
Chu Hedi-chaker
Sellami-Boudawara, Tahiya
Tunisia, Sfax
Chu Habib Bourguiba
Ghorbel, Abdelmonem
Tunisia, Sfax
Chu Habib Bourguiba
Gargouri, Ali Faouzi
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Jlidi, Rachid
Tunisia, Sfax
University of Sfax
Gargouri, Riadh
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Busson, Pierre
France, Villejuif
Signalisation, Noyaux et Innovations en Cancérologie
Drira, Mohamed Mokhtar
Tunisia, Sfax
Chu Hedi-chaker
Daoud, Jamel L.
Tunisia, Sfax
Chu Habib Bourguiba
Tunisia
Arome Association de Radiothérapie et D'oncologie de la Méditerranée
Frikha, Mounir F.
Tunisia, Sfax
Chu Habib Bourguiba
Tunisia
Arome Association de Radiothérapie et D'oncologie de la Méditerranée
Hammami, Adenène
Tunisia, Sfax
Chu Habib Bourguiba
Karray-Hakim, Héla
Tunisia, Sfax
Chu Habib Bourguiba
Statistics
Citations: 20
Authors: 20
Affiliations: 6
Identifiers
Doi:
10.1684/bdc.2010.1090
ISSN:
00074551
e-ISSN:
17696917
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Cohort Study
Study Locations
Multi-countries