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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Anti-inflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam.
South African Journal of Botany, Volume 74, No. 2, Year 2008
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Description
The effect of the flavonoid and saponin fractions from the leaves and root bark of Zizyphus lotus (200 mg/kg) was evaluated on carrageenan-induced paw edema in rats and on acetic acid-induced algesia in mice. In addition, two methanolic extracts from the plant (1 mg/ear) were tested on oxazolone-induced contact-delayed hypersensitivity (DTH) in mice. The effect of the different fractions was also evaluated in vitro on the nitrite production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages. The results showed that both the flavonoid and saponin fractions significantly inhibited paw edema, algesia, and nitrite production without affecting cell viability. Furthermore, the methanolic extracts of the leaves and root bark of Z. lotus were found to significantly inhibit the DTH induced by oxazolone, with the extract obtained from root bark being more active than that obtained from leaves. © 2007 SAAB.
Authors & Co-Authors
Borgi, Wahida
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Recio, María Carmen Carmen
Spain, Valencia
Universitat de València
Ŕios, José Luis
Spain, Valencia
Universitat de València
Chouchane, Nabil
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Statistics
Citations: 100
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.sajb.2008.01.009
ISSN:
02546299