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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria
Acta Tropica, Volume 95, No. 3, Year 2005
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Description
Mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes have been used as means to predict treatment failure to sulfadoxine-pyrimethamine (SP) and for monitoring/ surveillance of resistance to the drug in many areas where malaria is endemic. However, patients responses to treatment are significantly dependent on factors like host immunity profile of treated patients. In order to investigate the relationship between molecular markers of SP resistance, host immunity and clinical outcome, the association between pre-treatment dhfr and dhps genotypes, age and treatment outcomes was evaluated in 109 children treated with SP for acute uncomplicated malaria in Ibadan, Nigeria. Seventy-three percent of the children were cured with the drug, while 27% failed treatment after 28 days of follow-up. All children infected with parasites harboring less than two dhfr/dhps mutations were cured with SP. The dhfr triple (Asn-108/Ile-51/Arg-59) mutants or the dhps double mutants (Gly-437/Glu-540) were independently associated with SP treatment failure in children aged less than 5 years, but not in older children. The dhfr and dhps quintuple mutant (dhfr triple mutant + dhps double mutant) was the genotype most strongly associated with SP treatment failure (OR = 24.72, 95%CI = 8.24-74.15) in both younger and older children. © 2005 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Happi, Christian Tientcha
Nigeria, Ibadan
University of Ibadan
United States, Boston
Harvard T.h. Chan School of Public Health
Gbotosho, Grace Olusola
Nigeria, Ibadan
University of Ibadan
Folarin, Onikepe Abiola
Nigeria, Ibadan
University of Ibadan
Akinboye, Dora Olufunmilola
Nigeria, Ibadan
University of Ibadan
Yusuf, Oyindamola Bidemi
Nigeria, Ibadan
University of Ibadan
Ebong, O. O.
Nigeria, Port Harcourt
University of Port Hacourt
Sowunmi, Akintunde
Nigeria, Ibadan
University of Ibadan
Kyle, Dennis E.
United States, Silver Spring
Walter Reed Army Institute of Research
Milhous, Wilbur K.
United States, Silver Spring
Walter Reed Army Institute of Research
Wirth, Dyann F.
United States, Boston
Harvard T.h. Chan School of Public Health
Oduola, Ayoade M.J.
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 117
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1016/j.actatropica.2005.06.015
ISSN:
0001706X
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Nigeria