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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum
BMC Research Notes, Volume 5, Article 158, Year 2012
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Description
Background: Bryophyllum pinnatum (Lank.) Oken (Crassulaceae) is a perennial succulent herb widely used in traditional medicine to treat many ailments. Its wide range of uses in folk medicine justifies its being called "life plant" or "resurrection plant", prompting researchers' interest. We describe here the isolation and structure elucidation of antimicrobial and/or antioxidant components from the EtOAc extract of B. pinnatum. Results: The methanol extract displayed both antimicrobial activities with minimum inhibitory concentration (MIC) values ranging from 32 to 512 μg/ml and antioxidant property with an IC 50value of 52.48 μg/ml. Its partition enhanced the antimicrobial activity in EtOAc extract (MIC = 16-128 μg/ml) and reduced it in hexane extract (MIC = 256-1024 μg/ml). In addition, this process reduced the antioxidant activity in EtOAc and hexane extracts with IC 50values of 78.11 and 90.04 μg/ml respectively. Fractionation of EtOAc extract gave seven kaempferol rhamnosides, including; kaempferitrin (1), kaempferol 3-O-α-L-(2-acetyl)rhamnopyranoside-7-O-α-L- rhamnopyranoside (2), kaempferol 3-O-α-L-(3-acetyl)rhamnopyranoside-7-O- α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-(4-acetyl) rhamnopyranoside-7-O-α-L-rhamnopyranoside (4), kaempferol 3-O-α-D- glucopyranoside-7-O-α-L-rhamnopyranoside (5), afzelin (6) and α-rhamnoisorobin (7). All these compounds, except 6 were isolated from this plant for the first time. Compound 7 was the most active, with MIC values ranging from 1 to 2 μg/ml and its antioxidant activity (IC 50= 0.71 μg/ml) was higher than that of the reference drug (IC 50= 0.96 μg/ml). Conclusion: These findings demonstrate that Bryophyllum pinnatum and some of its isolated compounds have interesting antimicrobial and antioxidant properties, and therefore confirming the traditional use of B. pinnatum in the treatment of infectious and free radical damages. © 2011 Tatsimo Ndendoung et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Tatsimo, Simplice Joel Ndendoung
Cameroon, Maroua
Université de Maroua
Tamokou, Jean De Dieu
Cameroon, Dschang
University of Dschang
Havyarimana, Léopold
Burundi, Bujumbura
University of Burundi
Csupor, Dezső O.
Hungary, Szeged
Szegedi Tudományegyetem Szte
Forgó, Péter
Hungary, Szeged
Szegedi Tudományegyetem Szte
Hohmann, Judit
Hungary, Szeged
Szegedi Tudományegyetem Szte
Kuiaté, Jules Roger
Cameroon, Dschang
University of Dschang
Tané, Pierre
Cameroon, Dschang
University of Dschang
Statistics
Citations: 221
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1186/1756-0500-5-158
Research Areas
Health System And Policy