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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease
Nature Reviews Gastroenterology and Hepatology, Year 2023
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Description
Recompensation has gained increasing attention in the field of cirrhosis, particularly in chronic liver disease with a definite aetiology. The current global prevalence of obesity and nonalcoholic fatty liver disease (NAFLD) is increasing, but there is currently a lack of a clear definition for recompensation in NAFLD-related cirrhosis. Here, we provide an up-to-date perspective on the natural history of NAFLD, emphasizing the reversible nature of the disease, summarizing possible mechanisms underlying recompensation in NAFLD, discussing challenges that need to be addressed and outlining future research directions in the field. Recompensation is a promising goal in patients with NAFLD-related cirrhosis, and further studies are needed to explore its underlying mechanisms and uncover its clinical features. © 2023, Springer Nature Limited.
Authors & Co-Authors
Valenti, Luca Vittorio Carlo
Italy, Milan
Università Degli Studi Di Milano
Italy, Milan
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico
Wong, Vincent Wai Sun
Hong Kong, Hong Kong
Chinese University of Hong Kong
Fouad, Yasser Mahrous
Egypt, Minya
Minia University
Yilmaz, Yusuf
Turkey, Rize
Recep Tayyip Erdogan University
Kim, Won
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
Seoul Metropolitan Government - Seoul National University Borame Medical Center
Sebastiani, Giada
Canada, Montreal
Centre Universitaire de Santé Mcgill
Younossi, Zobair M.
United States, Falls Church
Inova
Hernández-Gea, Virginia
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Zheng, Minghua
China, Wenzhou
The First Affiliated Hospital of Wenzhou Medical University
China, Wenzhou
Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province
Statistics
Citations: 2
Authors: 9
Affiliations: 14
Identifiers
Doi:
10.1038/s41575-023-00846-4
ISSN:
17595045
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study