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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Echogenicity changes in the fetal brain, a 6-year follow-up study
Journal of Maternal-Fetal and Neonatal Medicine, Volume 26, No. 10, Year 2013
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Description
Objective: To asses the relation between echogenicity changes in the fetal brain and neurodevelopmental outcome until 6 years of age. Methods: Fetuses (n=124) from pregnancies affected by hypertensive disorders (n=64) or preterm labor (n=60) at risk for preterm birth (26-34 weeks gestation) were studied. Moderate echogenicity changes (periventricular grade IB, II; intraventricular grade II-III; local basal ganglia/thalami) in the fetal and neonatal brain were related to neurological outcome and Griffiths mental developmental scales quotients at 1, 2 and 6 years. Multiple regression analysis tested the influence of moderate echogenicity changes and perinatal clinical characteristics on composite outcome (death or abnormal neurodevelopment). Results: Moderate echogenicity changes were present in 37/124 (30%) fetuses. Median gestational age and weight at birth were respectively 31 weeks (range 26-43), 1314g (range 550-4330), mortality was 19%, follow-up loss 10%. Composite outcome was abnormal in 47/124 (38%). Fetal and neonatal moderate intraventricular echodensities were related to cerebral palsy at 6 years (p < 0.04). In the multiple regression analysis only gestational age was related to composite outcome (p=0.005). Conclusions: Moderate intraventricular echodensities in the fetal brain related to cerebral palsy at 6 years of age. Gestational age at birth was the main predictor of abnormal composite outcome. © 2013 Informa UK Ltd.
Authors & Co-Authors
Rosier-van Dunné, Fleur M.F.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
van Wezel-Meijler, Gerda
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Zwolle
Isala
de Groot, Laila
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
van Zyl, Jeanetta I.
South Africa, Tygerberg
Tygerberg Hospital
Odendaal, Hendrik J.
South Africa, Tygerberg
Tygerberg Hospital
de Vries, Johanna Inge Petra
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Statistics
Citations: 6
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.3109/14767058.2013.766693
ISSN:
14767058
e-ISSN:
14764954
Research Areas
Disability
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative