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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Cytotoxic sesquiterpene lactones and other constituents of centaurea omphalotricha
Journal of the Brazilian Chemical Society, Volume 23, No. 5, Year 2012
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Description
Phytochemical research of the aerial parts of Centaurea omphalotricha led to the isolation of three new sesquiterpene lactones, 4'-acetyl cynaropicrin, 4'-acetyl cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven sesquiterpene lactones, two isoprenoids and three flavonoids. The structures of the new compounds were elucidated by means of extensive 1D and 2D NMR, and MS, and by comparison with reported data in the literature. The effect of sesquiterpene lactones on the viability of the human tumor cell lines HL-60 and U937 was also investigated and 3-acetyl cynaropicrin, and 4'-acetyl cynaropicrin were found to be the most cytotoxic compounds against human leukemia cells with an IC50 values of 2.0 ± 0.9 and 5.1 ± 0.4 μmol L-1, respectively. © 2012 Sociedade Brasileira de Química.
Authors & Co-Authors
Kolli, El Hadj
Algeria, Constantine
Université Constantine 1
León, Francisco
Spain, San Cristobal de la Laguna
Csic - Instituto de Productos Naturales y Agrobiologia Ipna
Benayache, F.
Algeria, Constantine
Université Constantine 1
Estévez, Sara
Spain, Las Palmas de Gran Canaria
Universidad de Las Palmas de Gran Canaria
Quintana, José
Spain, Las Palmas de Gran Canaria
Universidad de Las Palmas de Gran Canaria
Estévez, Francisco
Spain, Las Palmas de Gran Canaria
Universidad de Las Palmas de Gran Canaria
Brouard, Ignacio
Spain, San Cristobal de la Laguna
Csic - Instituto de Productos Naturales y Agrobiologia Ipna
Bermejo, Jaime B.
Spain, San Cristobal de la Laguna
Csic - Instituto de Productos Naturales y Agrobiologia Ipna
Benayach, Samir
Algeria, Constantine
Université Constantine 1
Statistics
Citations: 27
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1590/S0103-50532012000500026
ISSN:
01035053
Research Areas
Cancer