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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Disappearance rates of plasma growth hormone after intravenous somatostatin in renal and liver disease
Journal of Clinical Endocrinology and Metabolism, Volume 41, No. 2, Year 1975
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Description
Plasma immunoreactive growth hormone (hGH) was measured before, during and after the administration of intravenous somatostatin to 3 patients with chronic renal failure and 4 with severe liver disease who had elevation of basal hGH. During somatostatin infusion, the hGH levels declined acutely in a linear fashion when log hGH was plotted against time. Rather surprisingly, the plasma hGH half disappearance time (Formula Presented) was 27 min and 18 min in liver and renal disease respectively. These values do not differ from data obtained on normal subjects using exogenous hGH, labelled or unlabelled. Control data on normal subjects using this technique are not available as it was not possible to measure subnormal levels of plasma hGH with the required precision. It is possible that our findings of plasma hGH (Formula Presented) in liver and renal disease within the normal range reported using exogenous hGH might suggest that high levels of plasma hGH found in these two diseases are primarily caused by hypersecretion rather than impaired clearance. © 1975 by The Endocrine Society.
Authors & Co-Authors
Pimstone, Bernard L.
South Africa, Observatory
Groote Schuur Hospital
LeRoith, Derek L.
South Africa, Observatory
Groote Schuur Hospital
Epstein, Solly E.
South Africa, Observatory
Groote Schuur Hospital
Kronheim, Shirley R.
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 35
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1210/jcem-41-2-392
ISSN:
0021972X
e-ISSN:
19457197