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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
B-Cell Immunodeficiency in Acquired Immune Deficiency Syndrome
JAMA: The Journal of the American Medical Association, Volume 251, No. 11, Year 1984
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Description
To investigate B-cell function in acquired immune deficiency syndrome (AIDS), we immunized a group of patients with AIDS with pneumococcal polysaccharide (tetradecavalent) and protein (keyhole-limpet hemocyanin) antigens. Antibody responses were determined three to four weeks after immunization. Compared with controls, patients with AIDS had significantly lower geometric mean antibody levels to polysaccharide before and after immunization. Levels before and after immunization were frequently below a level thought to correlate with protection. Patients with AIDS also had a significant reduction in their primary antibody response to the protein antigens. The results of these studies indicate that AIDS is associated with an acquired B-cell as well as T-cell immunodeficiency. It is suggested that future studies should consider the evaluation of passive antibody in the prevention of infection and/or prevention of progressive immunodeficiency. © 1984 American Medical Association. All rights reserved.
Authors & Co-Authors
Ammann, Arthur J.
United States, San Francisco
Ucsf Medical Center
Volberding, Paul A.
United States, San Francisco
Ucsf Medical Center
Ziegler, John L.
United States, San Francisco
San Francisco va Health Care System
Statistics
Citations: 240
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1001/jama.1984.03340350037024
ISSN:
00987484
Research Areas
Infectious Diseases
Maternal And Child Health