Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry
American Journal of Human Genetics, Volume 108, No. 4, Year 2021
Notification
URL copied to clipboard!
Description
Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combined and sex-stratified meta-analyses in up to 52,764 individuals with height and genome-wide genotyping data from the African Ancestry Anthropometry Genetics Consortium (AAAGC). We additionally combined our African ancestry meta-analysis results with published European genome-wide association study (GWAS) data. In the African ancestry analyses, we identified three novel loci (SLC4A3, NCOA2, ECD/FAM149B1) in sex-combined results and two loci (CRB1, KLF6) in women only. In the African plus European sex-combined GWAS, we identified an additional three novel loci (RCCD1, G6PC3, CEP95) which were equally driven by AAAGC and European results. Among 39 genome-wide significant signals at known loci, conditioning index SNPs from European studies identified 20 secondary signals. Two of the 20 new secondary signals and none of the 8 novel loci had minor allele frequencies (MAF) < 5%. Of 802 known European height signals, 643 displayed directionally consistent associations with height, of which 205 were nominally significant (p < 0.05) in the African ancestry sex-combined sample. Furthermore, 148 of 241 loci contained ≤20 variants in the credible sets that jointly account for 99% of the posterior probability of driving the associations. In summary, trans-ethnic meta-analyses revealed novel signals and further improved fine-mapping of putative causal variants in loci shared between African and European ancestry populations. © 2021 American Society of Human Genetics
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc2.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc3.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc4.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc5.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc6.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc7.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc8.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc9.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc10.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc11.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc12.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc13.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc14.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc15.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc16.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc17.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8059339/bin/mmc18.pdf
Authors & Co-Authors
Graff, Misa E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Justice, Anne E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Danville
Population Health Sciences
Young, Kristin L.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Marouli, Eirini
United Kingdom, London
Queen Mary University of London
Zhang, Xinruo
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Fine, Rebecca S.
United States, Boston
Vertex Pharmaceuticals, Inc.
Lim, Elise H.
United States, Boston
School of Public Health
Buchanan, Victoria L.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Rand, Kristin A.
United States, Los Angeles
University of Southern California
Feitosa, Mary Furlan
United States, St. Louis
Washington University School of Medicine in St. Louis
Wojczynski, Mary K.
United States, St. Louis
Washington University School of Medicine in St. Louis
Yanek, Lisa R.
United States, Baltimore
Johns Hopkins School of Medicine
Shao, Yaming
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Rohde, Rebecca R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Adeyemo, Adebowale A.
United States, Bethesda
National Institutes of Health Nih
Aldrich, Melinda C.
United States, Nashville
Vanderbilt University School of Medicine
Allison, Matthew A.
United States, La Jolla
University of California, San Diego
Ambrosone, Christine B.
United States, Buffalo
Roswell Park Cancer Institute
Ambs, Stefan
United States, Rockville
National Cancer Institute Nci
Amos, Christopher I.
United States, Houston
The University of Texas Md Anderson Cancer Center
Arnett, Donna K.
United States, Lexington
University of Kentucky
Atwood, Larry D.
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Bandera, E. V.
United States, New Brunswick
Rutgers Cancer Institute of new Jersey
Bartz, Traci M.
United States, Seattle
University of Washington
Becker, Diane M.
United States, Baltimore
Johns Hopkins School of Medicine
Berndt, Sonja I.
United States, Rockville
National Cancer Institute Nci
Bernstein, Leslie R.
United States, Duarte
City of Hope National Med Center
Bielak, Lawrence F.
United States, Ann Arbor
University of Michigan, Ann Arbor
Blot, William James
United States, Nashville
Vanderbilt University School of Medicine
United States, Rockville
International Epidemiology Institute
Böttinger, Erwin P.
United States, New York
Icahn School of Medicine at Mount Sinai
Bowden, Donald W.
United States, Winston Salem
Wake Forest University School of Medicine
Bradfield, Jonathan P.
United States, Philadelphia
The Children's Hospital of Philadelphia
Brody, Jennifer A.
United States, Seattle
University of Washington
Broeckel, Ulrich
United States, Milwaukee
Medical College of Wisconsin
Burke, Gregory L.
United States, Winston Salem
Wake Forest University School of Medicine
Cade, Brian E.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Cai, Qiuyin
United States, Nashville
Vanderbilt University School of Medicine
Caporaso, Neil E.
United States, Rockville
National Cancer Institute Nci
Carlson, Christopher S.
United States, Seattle
Fred Hutchinson Cancer Center
Carpten, John David
United States, Los Angeles
University of Southern California
Casey, Graham
United States, Los Angeles
University of Southern California
Chanock, Stephen J.
United States, Rockville
National Cancer Institute Nci
Chen, Guanjie
United States, Bethesda
National Institutes of Health Nih
Chen, Minhui
United States, Los Angeles
University of Southern California
Chen, Yii Der Ida
United States, Torrance
The Lundquist Institute
Chen, Weimin
United States, Charlottesville
University of Virginia School of Medicine
Chesi, Alessandra
United States, Philadelphia
The Children's Hospital of Philadelphia
Chiang, Charleston W.K.
United States, Los Angeles
University of Southern California
Chu, Lisa W.
United States, Fremont
Cancer Prevention Institute of California
Coetzee, Gerhard A.
United States, Los Angeles
University of Southern California
Conti, David V.
United States, Los Angeles
University of Southern California
Cooper, Richard S.
United States, Maywood
Loyola University Stritch School of Medicine
Cushman, Mary E.
United States, Burlington
University of Vermont Larner College of Medicine
Demerath, Ellen W.
United States, Minneapolis
School of Public Health
Deming, Sandra L.
United States, Nashville
Vanderbilt University School of Medicine
Dimitrov, Latchezar M.
United States, Winston Salem
Wake Forest University School of Medicine
Ding, Jingzhong
United States, Winston Salem
Wake Forest University School of Medicine
Diver, William Ryan
United States, Kennesaw
American Cancer Society
Duan, Qing
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Evans, Michele Kim
United States, Bethesda
National Institutes of Health Nih
Falusi, Adeyinka Gladys
Nigeria, Ibadan
University of Ibadan
Faul, Jessica D.
United States, Ann Arbor
University of Michigan, Ann Arbor
Fornage, Myriam
United States, Houston
University of Texas Health Science Center at Houston
Fox, Caroline S.
United States, Bethesda
National Institutes of Health Nih
United States, Framingham
Framingham Heart Study
United States, Boston
Brigham and Women's Hospital
Freedman, Barry I.
United States, Winston Salem
Wake Forest University School of Medicine
García, Melissa E.
United States, Bethesda
National Institutes of Health Nih
Gillanders, Elizabeth M.
United States, Rockville
National Cancer Institute Nci
Goodman, Phyllis J.
United States, Seattle
Fred Hutchinson Cancer Center
Gottesman, Omri
United States, New York
Icahn School of Medicine at Mount Sinai
Grant, Struan F.A.
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Guo, Xiuqing
United States, Torrance
The Lundquist Institute
Håkonarson, Håkon H.
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Haritunians, Talin
United States, Los Angeles
Cedars-sinai Medical Center
Harris, Tamara B.
United States, Bethesda
National Institutes of Health Nih
Harris, Curtis C.A.
United States, Rockville
National Cancer Institute Nci
Henderson, Brian E.
United States, Los Angeles
University of Southern California
Hennis, Anselm J.M.
United States, Stony Brook
Stony Brook University
Jamaica, Kingston
The University of the West Indies
Barbados, Bridgetown
Ministry of Health Barbados
Hernandez, Dena G.
United States, Bethesda
National Institutes of Health Nih
Hirschhorn, Joel N.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
McNeill, Lorna Haughton M.
United States, Houston
The University of Texas Md Anderson Cancer Center
Howard, Timothy D.
United States, Winston Salem
Wake Forest University School of Medicine
Howard, Barbara V.
United States, Hyattsville
Medstar Health Research Institute
Hsing, Ann Wu
United States, Fremont
Cancer Prevention Institute of California
United States, Stanford
Stanford University School of Medicine
Hsu, Yu Han Huang
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Hu, Jennifer J.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
United States, Miami
Florida International University
Huff, Chad D.
United States, Houston
The University of Texas Md Anderson Cancer Center
Huo, Dezheng
United States, Chicago
The University of Chicago
Ingles, Sue Ann
United States, Los Angeles
University of Southern California
Irvin, Marguerite Ryan
United States, Birmingham
The University of Alabama at Birmingham
John, Esther M.
United States, Stanford
Stanford University School of Medicine
Johnson, Karen Chandler
United States, Memphis
University of Tennessee Health Science Center
Jordan, Joanne Marie
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Kabagambe, Edmond Kato
United States, Birmingham
The University of Alabama at Birmingham
Kang, Sunjung
United States, Bethesda
National Institutes of Health Nih
Kardia, Sharon L.R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Keating, Brendan J.
United States, Philadelphia
University of Pennsylvania
Kittles, Rick A.
United States, Duarte
City of Hope National Med Center
Klein, Eric A.
United States, Cleveland
Cleveland Clinic Foundation
Kolb, Suzanne
United States, Seattle
Fred Hutchinson Cancer Center
Kolonel, Laurence N.
United States, Honolulu
University of Hawaiʻi Cancer Center
Kooperberg, Charles B.
United States, Seattle
Fred Hutchinson Cancer Center
Kuller, Lewis H.
United States, Pittsburgh
University of Pittsburgh
Kutlar, Abdullah
United States, Augusta
Augusta University
Lange, Leslie A.
United States, Aurora
University of Colorado Anschutz Medical Campus
Langefeld, Carl D.
United States, Winston Salem
Wake Forest University School of Medicine
Le Marchand, Loïc
United States, Honolulu
University of Hawaiʻi Cancer Center
Leonard, Hampton L.
United States, Bethesda
National Institutes of Health Nih
United States, Glen Echo
Data Tecnica International
Lettre, Guillaume
Canada, Montreal
Institut de Cardiologie de Montreal
Canada, Montreal
University of Montreal
Levin, Albert M.
United States, Detroit
Henry Ford Health System
Li, Yun
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Li, Jin
United States, Stanford
Stanford University School of Medicine
Liu, Yongmei
United States, Durham
Duke University
Liu, Youfang
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Liu, Simin
United States, Providence
Brown University
Lohman, Kurt K.
United States, Winston Salem
Wake Forest University School of Medicine
Lotay, Vaneet S.
United States, New York
Icahn School of Medicine at Mount Sinai
Lu, Yingchang
United States, Nashville
Vanderbilt University School of Medicine
United States, New York
Icahn School of Medicine at Mount Sinai
Maixner, William B.
United States, Durham
Duke University Medical Center
Manson, Jo Ann E.
United States, Boston
Brigham and Women's Hospital
McKnight, Barbara
United States, Seattle
University of Washington
Monda, Keri L.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Thousand Oaks
Amgen Incorporated
Monroe, Kristine R.
United States, Los Angeles
University of Southern California
Moore, Jason H.
United States, Philadelphia
University of Pennsylvania
Mosley, Thomas H.
United States, Jackson
University of Mississippi Medical Center
Mudgal, Poorva
United States, Winston Salem
Wake Forest University School of Medicine
Murphy, Adam Bryant
United States, Evanston
Northwestern University
Nadukuru, Rajiv
United States, New York
Icahn School of Medicine at Mount Sinai
Nalls, Mike A.
United States, Bethesda
National Institutes of Health Nih
United States, Glen Echo
Data Tecnica International
Nathanson, Katherine L.
United States, Philadelphia
University of Pennsylvania
Nayak, Uma
United States, Charlottesville
University of Virginia School of Medicine
N’Diaye, Amidou
Canada, Montreal
Institut de Cardiologie de Montreal
Nemesure, Barbara Berger
United States, Stony Brook
Stony Brook University
Neslund-Dudas, Christine M.
United States, Detroit
Henry Ford Health System
Neuhouser, Marian L.
United States, Seattle
Fred Hutchinson Cancer Center
Nyante, Sarah J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Ochs-Balcom, Heather M.
United States, Buffalo
University at Buffalo, the State University of new York
Ogundiran, Temidayo Olusade
Nigeria, Ibadan
University of Ibadan
Ogunniyi, Adesola O.
Nigeria, Ibadan
University of Ibadan
Ojengbede, Oladosu Akanbi
Nigeria, Ibadan
University of Ibadan
Okut, Hayrettin
United States, Winston Salem
Wake Forest University School of Medicine
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago Medicine
Olshan, Andrew F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Padhukasahasram, Badri K.
United States, Detroit
Henry Ford Health System
Palmer, Julie R.P.
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Palmer, Cameron D.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
Palmer, Nicholette (Nichole)
United States, Winston Salem
Wake Forest University
Papanicolaou, George John
United States, Bethesda
National Institutes of Health Nih
Patel, Sanjay R.
United States, Pittsburgh
University of Pittsburgh
Pettaway, Curtis A.
United States, Houston
The University of Texas Md Anderson Cancer Center
Peyser, Patricia A.
United States, Ann Arbor
University of Michigan, Ann Arbor
Press, Michael F.
United States, Los Angeles
University of Southern California
Rao, Dabeeru C.
United States, St. Louis
Washington University School of Medicine in St. Louis
Rasmussen-Torvik, Laura J.
United States, Chicago
Northwestern University Feinberg School of Medicine
Redline, Susan S.
United States, Boston
Brigham and Women's Hospital
Reiner, Alexander Paul
United States, Seattle
Fred Hutchinson Cancer Center
Rhie, Suhnkyong
United States, Los Angeles
University of Southern California
Rodriguez-Gil, Jorge L.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
United States, Miami
Florida International University
Rotimi, Charles N.
United States, Bethesda
National Institutes of Health Nih
Rotter, Jerome I.
United States, Torrance
The Lundquist Institute
Ruiz-Narváez, Edward A.
United States, Ann Arbor
University of Michigan School of Public Health
Rybicki, Benjamin A.
United States, Detroit
Henry Ford Health System
Salako, Babatunde Lawal
Nigeria, Ibadan
University of Ibadan
Sanderson, Maureen
United States, Nashville
Meharry Medical College
Schadt, Eric E.
United States, New York
Icahn School of Medicine at Mount Sinai
Schreiner, Pamela J.
United States, Minneapolis
School of Public Health
Schurmann, Claudia
United States, New York
Icahn School of Medicine at Mount Sinai
Shriner, Daniel A.
United States, Bethesda
National Institutes of Health Nih
Signorello, Lisa Beth
United States, Nashville
Vanderbilt University School of Medicine
United States, Rockville
International Epidemiology Institute
Singleton, Andrew B.
United States, Bethesda
National Institutes of Health Nih
Siscovick, David S.
United States, New York
New York Academy of Medicine
Smith, Jennifer Anne
United States, Ann Arbor
University of Michigan, Ann Arbor
Stanford, Janet L.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Stevens, Victoria L.
United States, Kennesaw
American Cancer Society
Stram, Alex H.
United States, Los Angeles
University of Southern California
Strom, Sara S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Sucheston-Campbell, Lara E.
United States, Buffalo
Roswell Park Cancer Institute
Sun, Yan V.
United States, Atlanta
Emory University
Tajuddin, Salman M.
United States, Bethesda
National Institutes of Health Nih
Taylor, Kira C.
United States, Louisville
University of Louisville
Tayo, Bamidele O.
United States, Maywood
Loyola University Stritch School of Medicine
Thun, Michael J.
United States, Kennesaw
American Cancer Society
Tucker, Margaret Anne
United States, Rockville
National Cancer Institute Nci
Vaidya, Dhananjay M.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
van den Berg, David J.
United States, Los Angeles
University of Southern California
Vedantam, Sailaja
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
Vitolins, Mara Z.
United States, Winston Salem
Wake Forest University School of Medicine
Wang, Zhaoming
United States, Memphis
St. Jude Children's Research Hospital
Ware, Erin B.
United States, Ann Arbor
University of Michigan, Ann Arbor
Wassertheil-Smoller, Sylvia
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Weir, David R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Wiencke, John Kevin
United States, San Francisco
University of California, San Francisco
Williams, Scott M.
United States, Cleveland
Case Western Reserve University
Williams, Lyn Keoki
United States, Detroit
Henry Ford Health System
Wilson, James Gaines
United States, Jackson
University of Mississippi Medical Center
Witte, John S.
United States, San Francisco
University of California, San Francisco
Wrensch, Margaret R.
United States, San Francisco
University of California, San Francisco
Wu, Xifeng
United States, Houston
The University of Texas Md Anderson Cancer Center
Yao, Jie
United States, Torrance
The Lundquist Institute
Zakai, Neil A.
United States, Burlington
University of Vermont Larner College of Medicine
Zanetti, Krista A.
United States, Rockville
National Cancer Institute Nci
Zemel, Babette S.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
United States, Philadelphia
The Children's Hospital of Philadelphia
Zhao, Wei
United States, Ann Arbor
University of Michigan, Ann Arbor
Zhao, Jinghua
United Kingdom, Cambridge
Mrc Epidemiology Unit
Zheng, Wei
United States, Nashville
Vanderbilt University School of Medicine
Zhi, Degui
United States, Houston
University of Texas Health Science Center at Houston
Zhou, Jie
United States, Bethesda
National Institutes of Health Nih
Ziegler, Regina G.
United States, Rockville
National Cancer Institute Nci
Zmuda, Joseph M.
United States, Pittsburgh
University of Pittsburgh
Zonderman, Alan B.
United States, Bethesda
National Institutes of Health Nih
Psaty, Bruce M.
United States, Seattle
University of Washington
Borecki, Ingrid B.
United States, St. Louis
Washington University School of Medicine in St. Louis
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Cupples, Laura Adrienne
United States, Boston
School of Public Health
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Liu, Chingti
United States, Boston
School of Public Health
Haiman, Christopher A.
United States, Los Angeles
University of Southern California
Loos, Ruth J.F.
United States, New York
Icahn School of Medicine at Mount Sinai
Ng, Maggie Chor Yin
United States, Winston Salem
Wake Forest University School of Medicine
North, Kari E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 19
Authors: 217
Affiliations: 87
Identifiers
Doi:
10.1016/j.ajhg.2021.02.011
ISSN:
00029297
Research Areas
Genetics And Genomics
Study Approach
Systematic review
Participants Gender
Female