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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cerebral magnesium levels in preeclampsia; A phosphorus magnetic resonance spectroscopy study
American Journal of Hypertension, Volume 30, No. 7, Year 2017
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Description
BACKGROUND Magnesium sulfate (MgSO4) is used as a prophylaxis for eclamptic seizures. The exact mechanism of action is not fully established. We used phosphorus magnetic resonance spectroscopy (31P-MRS) to investigate if cerebral magnesium (Mg2+) levels differ between women with preeclampsia, normal pregnant, and nonpregnant women. METHODS This cross-sectional study comprised 28 women with preeclampsia, 30 women with normal pregnancies in corresponding gestational week (range: 23-41 weeks) and 11 nonpregnant healthy controls. All women underwent 31P-MRS from the parieto-occipital region of the brain and were interviewed about cerebral symptoms. Differences between groups were assessed by analysis of variance and Tukey's post-hoc test. Correlations between Mg2+ levels and specific neurological symptoms were estimated with Spearman's rank test. RESULTS Mean maternal cerebral Mg2+ levels were lower in women with preeclampsia (0.12 mM ± 0.02) compared to normal pregnant controls (0.14 mM ± 0.03) (P = 0.04). Nonpregnant and normal pregnant women did not differ in Mg2+levels. Among women with preeclampsia, lower Mg2+ levels correlated with presence of visual disturbances (P = 0.04). Plasma levels of Mg2+ did not differ between preeclampsia and normal pregnancy. CONCLUSIONS Women with preeclampsia have reduced cerebral Mg2+ levels, which could explain the potent antiseizure prophylactic properties of MgSO4. Within the preeclampsia group, women with visual disturbances have lower levels of Mg2+ than those without such symptoms. © American Journal of Hypertension, Ltd 2017.
Authors & Co-Authors
Nelander, Maria
Sweden, Uppsala
Uppsala Universitet
Bergman, Lina
Sweden, Uppsala
Uppsala Universitet
Larsson, Anders Olof
Sweden, Uppsala
Uppsala Universitet
Wikstrom̈, Anna Karin
Sweden, Uppsala
Uppsala Universitet
Sweden, Stockholm
Department of Clinical Sciences, Danderyd Hospital
Wikström, Johan L.
Sweden, Uppsala
Uppsala Universitet
Statistics
Citations: 16
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1093/ajh/hpx022
ISSN:
08957061
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Female