Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp1
Gene, Volume 397, No. 1-2, Year 2007
Notification
URL copied to clipboard!
Description
Allelic dimorphism is a characteristic feature of the Plasmodium falciparum msp1 gene encoding the merozoite surface protein 1, a strong malaria vaccine candidate. Meiotic recombination is a major mechanism for the generation of msp1 allelic diversity. Potential recombination sites have previously been mapped to specific regions within msp1 (a 5′ 1-kb region and a 3′ 0.4-kb region) with no evidence for recombination events in a central 3.5-kb region. However, evidence for the lack of recombination events is circumstantial and inconclusive because the number of msp1 sequences analysed is limited, and the frequency of recombination events has not been addressed previously in a high transmission area, where the frequency of meiotic recombination is expected to be high. In the present study, we have mapped potential allelic recombination sites in 34 full-length msp1 sequences, including 24 new sequences, from various geographic origins. We also investigated recombination events in blocks 6 to 16 by population genetic analysis of P. falciparum populations in Tanzania, where malaria transmission is intense. The results clearly provide no evidence of recombination events occurring between the two major msp1 allelic types, K1-type and Mad20-type, in the central region, but do show recombination events occurring throughout the entire gene within sequences of the Mad20-type. Thus, the present study indicates that allelic dimorphism of msp1 greatly affects inter-allelic recombination events, highlighting a unique feature of allelic diversity of P. falciparum msp1. © 2007 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Tanabe, Kazuyuki
Unknown Affiliation
Sakihama, Naoko
Unknown Affiliation
Walliker, David
Unknown Affiliation
Babiker, Hamza Ali
Unknown Affiliation
Abdel-Muhsin, Abdel Muhsin A.
Unknown Affiliation
Bakote'e, Bernard
Unknown Affiliation
Ohmae, Hiroshi
Unknown Affiliation
Arisue, Nobuko
Unknown Affiliation
Horii, Toshihiro
Unknown Affiliation
Rooth, Ingegerd B.
Unknown Affiliation
Färnert, Anna
Unknown Affiliation
Bjǒrkman, Anders B.
Unknown Affiliation
Ranford-Cartwright, Lisa C.
Unknown Affiliation
Statistics
Citations: 36
Authors: 13
Affiliations: 9
Identifiers
Doi:
10.1016/j.gene.2007.04.033
ISSN:
03781119
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Tanzania