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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
Genes and Immunity, Volume 7, No. 5, Year 2006
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Description
The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved.
Authors & Co-Authors
Lõpez-Nevot, Miguel Ángel
Spain, Granada
Complejo Hospitalario Universitario de Granada
González-Gay, Miguel Ángel
Spain, Lugo
Complejo Hospitalario Xeral Calde
Sabio, José Marío
Spain, Granada
Complejo Hospitalario Universitario de Granada
Ortego-Centeno, Norberto
Spain, Granada
Hospital Universitario San Cecilio
de Rámon, Enrique
Spain, Malaga
Hospital Regional Universitario Carlos Haya
Anaya, Juan Manuel
Colombia, Bogota
Universidad Del Rosario
Gónzalez-Escribano, María Francisca
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Koeleman, Bobby P.C.
Netherlands, Utrecht
University Medical Center Utrecht
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Statistics
Citations: 86
Authors: 9
Affiliations: 9
Identifiers
Doi:
10.1038/sj.gene.6364310
ISSN:
14765470
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study