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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
Nature Communications, Volume 8, Article 14807, Year 2017
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Description
The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O 2-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates the rate of NO consumption by metabolizing NO in an O 2-dependent manner with decreased NO consumption in physiological hypoxia. Here we show that Cygb is a major regulator of NO degradation and cardiovascular tone. Knockout of Cygb greatly prolongs NO decay, increases vascular relaxation, and lowers blood pressure and systemic vascular resistance. We further demonstrate that downregulation of Cygb prevents angiotensin-mediated hypertension. Thus, Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and NOD activity of Cygb represents a strategy for the treatment of cardiovascular disease. © 2017 The Author(s).
Authors & Co-Authors
El-Mahdy, Mohamed A.
United States, Columbus
The Ohio State University
Hemann, Craig F.
United States, Columbus
The Ohio State University
Abdelghany, Tamer M.
United States, Columbus
The Ohio State University
Ismail, Raed Shahat
United States, Columbus
The Ohio State University
Thuy, Le Thi Thanh
Japan, Osaka
Osaka Metropolitan University Graduate School of Medicine
Kawada, Norifumi
Japan, Osaka
Osaka Metropolitan University Graduate School of Medicine
Zweíer, Jay L.
United States, Columbus
The Ohio State University
Statistics
Citations: 78
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1038/ncomms14807
ISSN:
20411723
Research Areas
Noncommunicable Diseases