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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Rapid spread of Vibrio cholerae O1 throughout Kenya, 2005
American Journal of Tropical Medicine and Hygiene, Volume 78, No. 3, Year 2008
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Description
Between January and June 2005, 5 distinct cholera outbreaks occurred in Kenya. Overall, 990 cases and 25 deaths (2.5%) were reported. Four outbreaks occurred in towns along major highways, and 1 occurred in a refugee camp near the Sudanese border, accessible to Nairobi by daily flights. Matched case-control studies from 2 outbreaks showed that failure to treat drinking water and storing drinking water in wide-mouthed containers were significantly associated with disease. Isolates from all 5 outbreaks were Vibrio cholerae O1, Inaba serotype, and had genetically similar PFGE patterns of SfiI-digested chromosomal DNA. Linkage of the outbreak locations by major transportation routes, their temporal proximity, and similar PFGE patterns of isolates suggests the outbreaks might have been linked epidemiologically, showing the speed and distance of cholera spread in countries like Kenya with pockets of susceptible populations connected by modern transportation. Prevention measures remain implementation of point-of-use safe water systems and case finding and referral. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Mugoya, Isaac
Kenya, Nairobi
Kenya Medical Research Institute
Kariuki, Samuel M.
Kenya, Nairobi
Kenyatta National Hospital
Galgalo, Tura Boru
Kenya, Nairobi
Kenya Medical Research Institute
Njuguna, Charles Kuria
Kenya, Nairobi
Disease Outbreak Management Unit
Omolo, Jared Odhiambo
Kenya, Nairobi
Kenya Medical Research Institute
Njoroge, Jackson
Kenya, Nairobi
Disease Outbreak Management Unit
Kalani, Rosalia M.
Kenya, Nairobi
Disease Outbreak Management Unit
Nzioka, Charles
Kenya, Nairobi
Disease Outbreak Management Unit
Tetteh, Christopher
Kenya, Nairobi
Kenya Medical Research Institute
Bedno, Sheryl A.
United States, Silver Spring
Walter Reed Army Institute of Research
Breiman, Robert F.
Kenya, Nairobi
Kenya Medical Research Institute
Feikin, Daniel R.
United States
Apo
Kenya, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 51
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2008.78.527
ISSN:
00029637
Research Areas
Environmental
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Case-Control Study
Study Locations
Kenya