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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
Proceedings of the National Academy of Sciences of the United States of America, Volume 120, No. 14, Article e2213880120, Year 2023
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Description
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case–control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case–control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case–control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case–control status. Subtle case–control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia. © 2023 National Academy of Sciences. All rights reserved.
Authors & Co-Authors
Schijven, Dick
Netherlands, Nijmegen
Max Planck Institute for Psycholinguistics
Postema, Merel Charlotte
Netherlands, Nijmegen
Max Planck Institute for Psycholinguistics
Netherlands, Amsterdam
Amsterdam Neuroscience
Fukunaga, Masaki
Japan, Okazaki
National Institutes of Natural Sciences - National Institute for Physiological Sciences
Matsumoto, Junya
Japan, Kodaira
National Center of Neurology and Psychiatry
Miura, Kenichiro
Japan, Kodaira
National Center of Neurology and Psychiatry
de Zwarte, Sonja M.C.
Netherlands, Utrecht
Universiteit Utrecht
van Haren, Neeltje E.M.
Netherlands, Utrecht
Universiteit Utrecht
Netherlands, Rotterdam
Erasmus Mc
Cahn, Wiepke
Netherlands, Utrecht
Universiteit Utrecht
Hulshoff Pol, Hilleke E.
Netherlands, Utrecht
Universiteit Utrecht
Kahn, René Sylvain
Netherlands, Utrecht
Universiteit Utrecht
United States, New York
Icahn School of Medicine at Mount Sinai
United States
Va Medical Center
Ayesa-Arriola, Rosa
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Santander
Universidad de Cantabria
de la Foz, Víctor Ortiz García
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Santander
Universidad de Cantabria
Tordesillas-Gutiérrez, Diana
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Spain, Santander
Csic-uc - Instituto de Física de Cantabria Ifca
Váquez-Bourgon, Javier
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Spain, Madrid
Instituto de Salud Carlos Iii
Crespo-Facorro, Benedicto
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Alnæs, Dag
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Bjorknes University College
Dahl, Andreas
Norway, Oslo
Universitetet I Oslo
Westlye, Lars T.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Agartz, Ingrid A.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Sweden, Stockholm
Karolinska Institutet
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Jönsson, Erik Gunnar
Norway, Oslo
Universitetet I Oslo
Sweden, Stockholm
Karolinska Institutet
Kochunov, Peter V.
United States, Baltimore
University of Maryland School of Medicine
Bruggemann, Jason M.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
Australia, Sydney
Edith Collins Centre Translational Research in Alcohol Drugs and Toxicology
Australia, Sydney
The University of Sydney
Catts, Stanley Victor
Australia, Brisbane
The University of Queensland
Michie, Patricia Therese
Australia, Callaghan
The University of Newcastle, Australia
Mowry, Bryan J.
Australia, Brisbane
The University of Queensland
Quidé, Yann
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
Rasser, Paul E.
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Schall, Ulrich
Australia, Callaghan
The University of Newcastle, Australia
Scott, Rodney J.
Australia, Callaghan
The University of Newcastle, Australia
Carr, Vaughan James
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
Green, Melissa J.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
Henskens, Frans Alexander
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter Medical Research Institute, Australia
Loughland, Carmel Maree
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
Hunter new England Mental Health Service
Pantelis, Christos S.
Australia, Melbourne
University of Melbourne
Shannon Weickert, Cynthia
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
United States, Syracuse
Suny Upstate Medical University
Weickert, Thomas W.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
United States, Syracuse
Suny Upstate Medical University
de Haan, Lieuwe
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Netherlands, Amsterdam
Arkin Mental Health Care Institute
Brosch, Katharina
Germany, Marburg
Philipps-universität Marburg
Germany, Marburg
Brain and Behavior
Pfarr, Julia Katharina
Germany, Marburg
Philipps-universität Marburg
Germany, Marburg
Brain and Behavior
Ringwald, Kai Gustav
Germany, Marburg
Philipps-universität Marburg
Germany, Marburg
Brain and Behavior
Stein, Frederike
Germany, Marburg
Philipps-universität Marburg
Germany, Marburg
Brain and Behavior
Jansen, Andreas
Germany, Marburg
Philipps-universität Marburg
Germany, Marburg
Brain and Behavior
Kircher, Tilo T.J.
Germany, Marburg
Philipps-universität Marburg
Germany, Marburg
Brain and Behavior
Nenadić, Igor
Germany, Marburg
Philipps-universität Marburg
Germany, Marburg
Brain and Behavior
Krämer, Bernd K.
Germany, Heidelberg
Universität Heidelberg
Gruber, Oliver
Germany, Heidelberg
Universität Heidelberg
Satterthwaite, Theodore Daniel
United States, Philadelphia
University of Pennsylvania
Bustillo, Juan R.
United States, Albuquerque
The University of new Mexico
Mathalon, Daniel H.
United States, San Francisco
University of California, San Francisco
United States, San Francisco
San Francisco va Health Care System
Preda, Adrian
United States, Irvine
University of California, Irvine
Calhoun, Vince D.
United States, Atlanta
Georgia State University
United States, Atlanta
Georgia Institute of Technology
Ford, Judith M.
United States, San Francisco
San Francisco va Health Care System
Potkin, Steven G.
United States, Irvine
University of California, Irvine
United States, Long Beach
Va Long Beach Healthcare System
Chen, Jingxu
China, Beijing
Beijing Huilongguan Hospital
Tan, Yunlong
China, Beijing
Beijing Huilongguan Hospital
Wang, Zhiren
China, Beijing
Beijing Huilongguan Hospital
Xiang, Hong
China, Chongqing
Chongqing University
Fan, Fengmei
China, Beijing
Beijing Huilongguan Hospital
Bernardoni, Fabio
Germany, Dresden
Technische Universität Dresden
Germany, Dresden
Universitätsklinikum Carl Gustav Carus Dresden
Ehrlich, Stefan
Germany, Dresden
Technische Universität Dresden
Germany, Dresden
Universitätsklinikum Carl Gustav Carus Dresden
Fuentes-Claramonte, Paola
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Mental Health Research Networking Center Ciber Del Área de Salud Mental
García-León, María Ángeles
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Mental Health Research Networking Center Ciber Del Área de Salud Mental
Guerrero-Pedraza, Amalia
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Sant Boi de Llobregat
Hospital Benito Menni
Salvador, Raymond
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Mental Health Research Networking Center Ciber Del Área de Salud Mental
Sarró, Salvador
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Mental Health Research Networking Center Ciber Del Área de Salud Mental
Pomarol-Clotet, Edith
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Mental Health Research Networking Center Ciber Del Área de Salud Mental
Ciullo, Valentina
Italy, Rome
Irccs Fondazione Santa Lucia
Piras, Fabrizio
Italy, Rome
Irccs Fondazione Santa Lucia
Vecchio, Daniela
Italy, Rome
Irccs Fondazione Santa Lucia
Banaj, Nerisa
Italy, Rome
Irccs Fondazione Santa Lucia
Spalletta, Gianfranco
Italy, Rome
Irccs Fondazione Santa Lucia
United States, Houston
Baylor College of Medicine
Michielse, Stijn
Netherlands, Maastricht
Universiteit Maastricht
van Amelsvoort, Thérèse A.M.J.
Netherlands, Maastricht
Universiteit Maastricht
Dickie, Erin W.
Canada, Toronto
Centre for Addiction and Mental Health
Canada, Toronto
University of Toronto
Voineskos, Aristotle N.
Canada, Toronto
Centre for Addiction and Mental Health
Canada, Toronto
University of Toronto
Sim, Kang
Singapore, Singapore City
Singapore Institute of Mental Health
Singapore, Singapore City
National University of Singapore
Ciufolini, Simone
United Kingdom, London
King's College London
Dazzan, Paola
United Kingdom, London
King's College London
Murray, Robin Mac Gregor
United Kingdom, London
King's College London
Kim, Woosung
South Korea, Jeonju
Jeonbuk National University, School of Medicine
South Korea, Jeonju
Jeonbuk National University
Chung, Young-chul
South Korea, Jeonju
Jeonbuk National University, School of Medicine
South Korea, Jeonju
Jeonbuk National University
Andreou, Christina
Switzerland, Basel
Universitat Basel
Germany, Lubeck
Universität zu Lübeck
Schmidt, Andrej C.
Switzerland, Basel
Universitat Basel
Borgwardt, Stefan J.
Switzerland, Basel
Universitat Basel
Germany, Lubeck
Universität zu Lübeck
McIntosh, Andrew M.
United Kingdom, Edinburgh
The University of Edinburgh
Whalley, Heather Clare
United Kingdom, Edinburgh
The University of Edinburgh
Lawrie, Stephen M.
United Kingdom, Edinburgh
The University of Edinburgh
Du Plessis, Stéfan
South Africa, Stellenbosch
Stellenbosch University
South Africa, Tygerberg
South African Medical Research Council
Lückhoff, Hilmar Klaus
South Africa, Stellenbosch
Stellenbosch University
Scheffler, Freda
South Africa, Stellenbosch
Stellenbosch University
South Africa, Cape Town
University of Cape Town
Emsley, Robin
South Africa, Stellenbosch
Stellenbosch University
Grotegerd, Dominik
Germany, Munster
University of Münster
Lencer, Rebekka M.
Germany, Lubeck
Universität zu Lübeck
Germany, Munster
University of Münster
Dannlowski, Udo
Germany, Munster
University of Münster
Edmond, Jesse T.
United States, Atlanta
Georgia State University
Rootes-Murdy, Kelly
United States, Atlanta
Georgia State University
Stephen, Julia M.
United States, Albuquerque
The Mind Research Network
Mayer, Andrew R.
United States, Albuquerque
The Mind Research Network
Antonucci, Linda Antonella
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Pergola, Giulio
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Bertolino, Alessandro
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Díaz-Caneja, Covadonga Martinez
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Madrid
Instituto de Investigación Sanitaria Gregorio Marañón
Spain, Madrid
Universidad Complutense de Madrid
Janssen, Joost
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Madrid
Instituto de Investigación Sanitaria Gregorio Marañón
Arango, Celso
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Madrid
Instituto de Investigación Sanitaria Gregorio Marañón
Spain, Madrid
Universidad Complutense de Madrid
Tomyshev, Alexander S.
Russian Federation, Moscow
Federal State Budget Scientific Institution Scientific Center of Mental Health
Lebedeva, Irina S.
Russian Federation, Moscow
Federal State Budget Scientific Institution Scientific Center of Mental Health
Červenka, Simon
Sweden, Stockholm
Karolinska Institutet
Sweden, Uppsala
Uppsala Universitet
Sellgren, Carl M.
Sweden, Stockholm
Karolinska Institutet
Georgiadis, Foivos
Switzerland, Zurich
Psychiatrische Universitätsklinik Zürich
Kirschner, Matthias
Switzerland, Zurich
Psychiatrische Universitätsklinik Zürich
Canada, Montreal
Université Mcgill
Kaiser, Stefan Ren
Switzerland, Zurich
Psychiatrische Universitätsklinik Zürich
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Haj́ek, Tomaś
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Canada, Halifax
Dalhousie University
Škoch, Antonín
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Czech Republic, Prague
Institutu Klinické a Experimentální Medicíny
Španiel, Filip A.
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Kim, Minah
South Korea, Seoul
Seoul National University College of Medicine
Kwak, Yoobin
South Korea, Seoul
College of Natural Sciences
Oh, Sanghoon
South Korea, Seoul
Seoul National University College of Medicine
Kwon, Junsoo
South Korea, Seoul
Seoul National University Hospital
South Korea, Seoul
Seoul National University College of Medicine
James, Anthony C.
United Kingdom, Oxford
University of Oxford
Bakker, Geor
Netherlands, Maastricht
Universiteit Maastricht
Knöchel, Christian
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Stäblein, Michael
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Oertel-Knöchel, Viola
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Uhlmann, Anne
South Africa, Cape Town
University of Cape Town
Germany, Dresden
Technische Universität Dresden
Howells, Fleur Margaret
South Africa, Cape Town
University of Cape Town
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Temmingh, Henk S.
South Africa, Cape Town
University of Cape Town
Diáz-Zuluaga, Ana María
Colombia, Medellin
Universidad de Antioquia
Pineda-Zapata, Julián Alberto
Colombia, Medellin
Universidad de Antioquia
López-Jaramillo, Carlos Alberto
Colombia, Medellin
Universidad de Antioquia
Homan, Stephanie
Switzerland, Zurich
Psychiatrische Universitätsklinik Zürich
Switzerland, Zurich
Universität Zürich
Ji, Ellen
Switzerland, Zurich
Psychiatrische Universitätsklinik Zürich
Homan, Philipp
Switzerland, Zurich
Psychiatrische Universitätsklinik Zürich
United States, Manhasset
Feinstein Institute for Medical Research
United States, New York
Northwell Health System
United States, Hempstead
Donald and Barbara Zucker School of Medicine at Hofstra/northwell
Fisher, Simon E.
Netherlands, Nijmegen
Max Planck Institute for Psycholinguistics
Netherlands, Nijmegen
Radboud Universiteit
Franke, Barbara
Netherlands, Nijmegen
Radboud Universiteit
Netherlands, Nijmegen
Radboud University Medical Center
Gur, Ruben C.
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Jahanshad, Neda
United States, Los Angeles
University of Southern California
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Turner, Jessica A.
United States, Atlanta
Georgia State University
United States, Atlanta
Georgia Institute of Technology
van Erp, Theo G.M.
United States, Irvine
University of California, Irvine
Francks, Clyde
Netherlands, Nijmegen
Max Planck Institute for Psycholinguistics
Netherlands, Nijmegen
Radboud Universiteit
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 6
Authors: 142
Affiliations: 98
Identifiers
Doi:
10.1073/pnas.2213880120
ISSN:
00278424
Research Areas
Mental Health