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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians
Genes and Immunity, Volume 8, No. 4, Year 2007
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Description
Tumor necrosis factor (TNF) is thought to be a key mediator of the inflammatory and fibrotic response to Chlamydia trachomatis (Ct) infection. A large matched-pair case-control study investigated putative functional single nucleotide polymorphisms (SNPs) across the major histocompatibility complex (MHC) class III region, including TNF and its immediate neighbors nuclear factor of κ light polypeptide gene enhancer in B cells (IκBL), inhibitor like 1 and lymphotoxin alpha (LTA) in relation to the risk of scarring sequelae of ocular Ct infection. Haplotype and linkage disequilibrium analysis demonstrated two haplotypes, differing at position TNF-308, conferring an increased risk of trichiasis. The TNF-308A allele, and its bearing haplotype, correlated with increased TNF production in lymphocyte cultures stimulated with chlamydial elementary body antigen. Thus TNF-308A may determine directly, or be a marker of a high TNF producer phenotype associated with increased risk of sequelae of chlamydial infection. Multivariate analysis provided evidence for the presence of additional risk-associated variants near the TNF locus. © 2007 Nature Publishing Group.
Authors & Co-Authors
Natividad, Angels
United Kingdom, London
University of London
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Hanchard, Neil A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Holland, Martin J.
United Kingdom, London
University of London
Mahdi, O. S.M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Diakité, Mahamadou L.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Rockett, Kirk A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Jallow, Ousman
Gambia, Banjul
National Eye Care Programme
Joof, H. M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Kwiatkowski, Dominic P.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Mabey, David C.W.
United Kingdom, London
University of London
Bailey, Robin L.
United Kingdom, London
University of London
Statistics
Citations: 59
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1038/sj.gene.6364384
ISSN:
14664879
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study