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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
An experimental vaccine cocktail for Plasmodium falciparum malaria
Vaccine, Volume 11, No. 4, Year 1993
Notification
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Description
Surface proteins from several different life-cycle stages of the malaria parasite Plasmodium falciparum were expressed at high levels in the yeast Saccharomyces cerevisiae. Purified proteins, both individually and in cocktails, were used to immunize mice and goats in conjunction with either Freund's adjuvant or a muramyl tripeptide-based adjuvant. Immune responses were measured by enzyme-linked immunosorbent assays and by the ability of antisera to inhibit (1) the invasion of hepatocytes by live sporozoites, (2) in vitro invasion of human erythrocytes by live merozoites, and (3) the development of oocytes in the mosquito vector. These results suggest that cocktails of different stage-specific antigens can provide the components necessary to block the development of the malaria parasite at multiple stages of its life cycle. © 1993.
Authors & Co-Authors
Bathurst, Ian C.
Unknown Affiliation
Chang, Sandra P.
United States, Honolulu
Leahi Hospital
Inselburg, Joseph W.
United States, Hanover
Geisel School of Medicine at Dartmouth
Millet, Pascal G.
United States, Atlanta
Centers for Disease Control and Prevention
Quakyi, Isabella Akyinbah
United States, Bethesda
National Institute of Allergy and Infectious Diseases
Kaslow, David C.
United States, Bethesda
National Institute of Allergy and Infectious Diseases
Barr, Philip J.
Switzerland, Basel
Novartis International ag
Statistics
Citations: 24
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/0264-410X(93)90287-8
ISSN:
0264410X
Research Areas
Infectious Diseases