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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of gum arabic (Acacia senegal) on renal function in diabetic mice
Kidney and Blood Pressure Research, Volume 35, No. 5, Year 2012
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Description
Background/Aims: Gum arabic (GA) is a Ca2+-, Mg2+- and K+-rich dietary fiber used for the treatment of patients with chronic kidney disease in Middle Eastern countries. In healthy mice, GA treatment increases creatinine clearance, renal ADH excretion, as well as intestinal and renal excretion of Mg2+ and Ca2+. GA decreases plasma Pi concentration, urinary Pi and Na+ excretion. The present study explored the effects of GA on renal function in diabetic mice. Methods: Metabolic cage experiments were performed on Akita mice (akita +/-), which spontaneously develop insulin deficiency and thus hyperglycemia. Plasma and urinary concentrations of Na+, K + and Ca2+ were measured by flame photometry (AFM 5051, Eppendorf, Germany), creatinine by the Jaffé method, phosphate photometrically, urea by an enzymatic method, glucose utilizing a glucometer and an enzymatic kit, aldosterone using an RIA, urinary albumin fluorometrically, and blood pressure by the tail-cuff method. Results: GA (10% in drinking water) significantly increased urinary excretion of Ca2+ and significantly decreased plasma phosphate and urea concentrations, urinary flow rate, urinary Na+, phosphate and glucose excretion, blood pressure and proteinuria. Conclusions: GA treatment decreases blood pressure and proteinuria in diabetic mice and may thus prove beneficial in diabetic nephropathy. Copyright © 2012 S. Karger AG.
Authors & Co-Authors
Nasir, Omaima
Germany, Tubingen
Eberhard Karls Universität Tübingen
Umbach, Anja T.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Rexhepaj, Rexhep
Germany, Tubingen
Eberhard Karls Universität Tübingen
Ackermann, Teresa F.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Bhandaru, Madhuri
Germany, Tubingen
Eberhard Karls Universität Tübingen
Ebrahim, Ammar
Germany, Tubingen
Eberhard Karls Universität Tübingen
Artunç, Ferruh H.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kempe, Daniela S.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Puchchakayala, Goverdhan
Germany, Tubingen
Eberhard Karls Universität Tübingen
Siraskar, Balasaheb
Germany, Tubingen
Eberhard Karls Universität Tübingen
Föller, Michael
Germany, Tubingen
Eberhard Karls Universität Tübingen
Saeed, Amal Mahmoud
Sudan, Khartoum
Khartoum University
Lang, Florian C.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 55
Authors: 13
Affiliations: 2
Identifiers
Doi:
10.1159/000336359
ISSN:
14204096
e-ISSN:
14230143
Research Areas
Environmental
Noncommunicable Diseases
Study Locations
Senegal